Rolf E Brenner
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Explore the profile of Rolf E Brenner including associated specialties, affiliations and a list of published articles.
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70
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1324
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Recent Articles
1.
Maurer S, Fuchs M, Brenner R, Riegger J
Heliyon
. 2024 Dec;
10(22):e40368.
PMID: 39624277
Joint injuries and consequent oxidative stress is a high-risk factor for developing post-traumatic osteoarthritis (OA). While antioxidative therapy using N-acetylcysteine (NAC) has cell- and chondroprotective effects following cartilage injury, it...
2.
Maurer S, Kirsch V, Ruths L, Brenner R, Riegger J
Aging Cell
. 2024 Oct;
24(1):e14361.
PMID: 39402753
Cellular senescence is associated with various age-related disorders and is assumed to play a major role in the pathogenesis of osteoarthritis (OA). Based on this, we tested a senolytic combination...
3.
Kuhn A, Huber-Lang M, Weckbach S, Riegger J, Teixeira G, Rasche V, et al.
Biomedicines
. 2024 Aug;
12(8).
PMID: 39200157
Previous studies indicate an implication of the terminal complement complex (TCC) in disc degeneration (DD). To investigate the functional role of TCC in trauma-induced DD in vivo, the model of...
4.
Riegger J, Brenner R
Elife
. 2023 Oct;
12.
PMID: 37855367
Accumulation of dysfunctional chondrocytes has detrimental consequences on the cartilagehomeostasis and is thus thought to play a crucial role during the pathogenesis of osteoarthritis(OA). However, the underlying mechanisms of phenotypical...
5.
Kuhn A, Riegger J, Teixeira G, Huber-Lang M, Lambris J, Neidlinger-Wilke C, et al.
Cells
. 2023 Mar;
12(6).
PMID: 36980228
Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular...
6.
Riegger J, Joos H, Mohler V, Leucht F, Rading K, Kubisch C, et al.
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830586
The terminal complement complex (TCC) has been described as a potential driver in the pathogenesis of posttraumatic osteoarthritis (PTOA). However, sublytic TCC deposition might also play a crucial role in...
7.
Riegger J, Maurer S, Pulasani S, Brenner R
Front Bioeng Biotechnol
. 2022 Sep;
10:965302.
PMID: 36159664
Joint injuries are known to induce pathomechanisms that might lead to posttraumatic osteoarthritis (PTOA). In this regard, statins with their pleiotropic effects could represent potential therapeutic agents in preventing the...
8.
Huber L, Gvaramia D, Kern J, Jakob Y, Zoellner F, Hirsch D, et al.
J Tissue Eng
. 2022 Sep;
13:20417314221114423.
PMID: 36158899
Nasal septum defects can currently only be reconstructed using autologous cartilage grafts. In this study, we examine the reconstruction of septal cartilage defects in a rabbit model using porcine decellularized...
9.
Tews D, Brenner R, Siebert R, Debatin K, Fischer-Posovszky P, Wabitsch M
Int J Obes (Lond)
. 2022 Aug;
46(11):1939-1947.
PMID: 35986215
20 years ago, we described a human cell strain derived from subcutaneous adipose tissue of an infant supposed to have Simpson-Golabi-Behmel Syndrome (SGBS), thus called "SGBS cells". Since then, these...
10.
Modulation of the inflammatory response to decellularized collagen matrix for cartilage regeneration
Gvaramia D, Kern J, Jakob Y, Tritschler H, Brenner R, Breiter R, et al.
J Biomed Mater Res A
. 2021 Dec;
110(5):1021-1035.
PMID: 34967101
Decellularized extracellular matrices (DECM) are among the most common types of materials used in tissue engineering due to their cell instructive properties, biodegradability, and accessibility. Particularly in cartilage, a natural...