Roland Sonntag
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Explore the profile of Roland Sonntag including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
275
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Recent Articles
1.
Rahn K, Abdallah A, Gan L, Herbrich S, Sonntag R, Benitez O, et al.
Biochim Biophys Acta Gene Regul Mech
. 2023 Nov;
1867(1):195004.
PMID: 38008244
Deletions on the long arm of chromosome 9 (del(9q)) are recurrent abnormalities in about 2 % of acute myeloid leukemia cases, which usually involve HNRNPK and are frequently associated with...
2.
Otto J, Verwaayen A, Penners C, Hundertmark J, Lin C, Kallen C, et al.
Cell Death Dis
. 2023 Aug;
14(8):549.
PMID: 37620309
Hepatocellular carcinoma (HCC) is one of the most severe malignancies with increasing incidence and limited treatment options. Typically, HCC develops during a multistep process involving chronic liver inflammation and liver...
3.
Capellmann S, Sonntag R, Schuler H, Meurer S, Gan L, Kauffmann M, et al.
Front Immunol
. 2023 Apr;
14:1154416.
PMID: 37063827
Mast cells (MCs) are immune cells of the myeloid lineage distributed in tissues throughout the body. Phenotypically, they are a heterogeneous group characterized by different protease repertoires stored in secretory...
4.
Mainz R, Albers S, Haque M, Sonntag R, Treichel N, Clavel T, et al.
Cells
. 2022 Jan;
11(2).
PMID: 35053298
A considerable percentage of the population is affected by alcoholic liver disease (ALD). It is characterized by inflammatory signals from the liver and other organs, such as the intestine. The...
5.
Sonntag R, Penners C, Kohlhepp M, Haas U, Lambertz D, Kroh A, et al.
Cancers (Basel)
. 2021 Nov;
13(22).
PMID: 34830835
Cyclin E1 (CCNE1) is a regulatory subunit of Cyclin-dependent kinase 2 (CDK2) and is thought to control the transition of quiescent cells into cell cycle progression. Recently, we identified CCNE1...
6.
Hubbers A, Hennings J, Lambertz D, Haas U, Trautwein C, Nevzorova Y, et al.
Int J Mol Sci
. 2020 May;
21(9).
PMID: 32380742
Liver fibrosis is a wound healing process in response to chronic liver injury, which is characterized by the accumulation of extracellular collagen produced by Hepatic Stellate Cells (HSCs). This process...
7.
Roy S, Hooiveld G, Seehawer M, Caruso S, Heinzmann F, Schneider A, et al.
Gastroenterology
. 2018 Aug;
155(6):1951-1966.e26.
PMID: 30165047
Background & Aims: We performed an integrated analysis to identify microRNAs (miRNAs) and messenger RNAs (mRNAs) with altered expression in liver tumors from 3 mouse models of hepatocellular carcinoma (HCC)...
8.
Sonntag R, Giebeler N, Nevzorova Y, Bangen J, Fahrenkamp D, Lambertz D, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(37):9282-9287.
PMID: 30150405
E-type cyclins E1 (CcnE1) and E2 (CcnE2) are regulatory subunits of cyclin-dependent kinase 2 (Cdk2) and thought to control the transition of quiescent cells into the cell cycle. Initial findings...
9.
Hao F, Cubero F, Ramadori P, Liao L, Haas U, Lambertz D, et al.
Cell Death Dis
. 2017 Oct;
8(10):e3152.
PMID: 29072704
Hepatic apoptosis is involved in the progression of alcoholic liver disease (ALD). Caspase-8, the apical initiator in death receptor-mediated apoptosis, has been implicated in acute liver injury and in non-alcoholic...
10.
Bangen J, Hammerich L, Sonntag R, Baues M, Haas U, Lambertz D, et al.
Hepatology
. 2017 May;
66(4):1242-1257.
PMID: 28520165
Conclusion: Therapeutic targeting of CcnE1 in vivo using RNAi is feasible and has high antifibrotic activity. (Hepatology 2017;66:1242-1257).