Roland C Grafstrom
Overview
Explore the profile of Roland C Grafstrom including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
459
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0
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Recent Articles
1.
Dumit V, Liu Y, Bahl A, Kohonen P, Grafstrom R, Nymark P, et al.
Adv Sci (Weinh)
. 2023 Dec;
11(9):e2306268.
PMID: 38116877
The Fiber Pathogenicity Paradigm (FPP) establishes connections between fiber structure, durability, and disease-causing potential observed in materials like asbestos and synthetic fibers. While emerging nanofibers are anticipated to exhibit pathogenic...
2.
Nymark P, Kohonen P, Hongisto V, Grafstrom R
Ann Am Thorac Soc
. 2018 Apr;
15(Suppl 2):S91-S97.
PMID: 29676641
An immense variety of different types of engineered nanomaterials are currently being developed and increasingly applied to consumer products. Importantly, engineered nanomaterials may pose unexplored adverse health effects because of...
3.
Nymark P, Rieswijk L, Ehrhart F, Jeliazkova N, Tsiliki G, Sarimveis H, et al.
Toxicol Sci
. 2017 Nov;
162(1):264-275.
PMID: 29149350
Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and informatics-tool supported pipeline schemas for fitting such data into Adverse Outcome...
4.
Kohonen P, Parkkinen J, Willighagen E, Ceder R, Wennerberg K, Kaski S, et al.
Nat Commun
. 2017 Jul;
8:15932.
PMID: 28671182
Predicting unanticipated harmful effects of chemicals and drug molecules is a difficult and costly task. Here we utilize a 'big data compacting and data fusion'-concept to capture diverse adverse outcomes...
5.
Kohonen P, Benfenati E, Bower D, Ceder R, Crump M, Cross K, et al.
Mol Inform
. 2016 Aug;
32(1):47-63.
PMID: 27481023
The aim of the SEURAT-1 (Safety Evaluation Ultimately Replacing Animal Testing-1) research cluster, comprised of seven EU FP7 Health projects co-financed by Cosmetics Europe, is to generate a proof-of-concept to...
6.
Grafstrom R, Nymark P, Hongisto V, Spjuth O, Ceder R, Willighagen E, et al.
Altern Lab Anim
. 2015 Nov;
43(5):325-32.
PMID: 26551289
This paper outlines the work for which Roland Grafström and Pekka Kohonen were awarded the 2014 Lush Science Prize. The research activities of the Grafström laboratory have, for many years,...
7.
Jerhammar F, Johansson A, Ceder R, Welander J, Jansson A, Grafstrom R, et al.
Oral Oncol
. 2014 Jul;
50(9):832-9.
PMID: 24993889
Objectives: Targeted therapy against the epidermal growth factor receptor (EGFR) only variably represents a therapeutic advance in head and neck squamous cell carcinoma (HNSCC). This study addresses the need of...
8.
Ottosson-Wadlund A, Ceder R, Preta G, Pokrovskaja K, Grafstrom R, Heyman M, et al.
Mol Pharmacol
. 2012 Oct;
83(1):245-55.
PMID: 23093495
Bortezomib is a highly selective inhibitor of the 26S proteasome and has been approved for clinical use in the treatment of relapsing and refractory multiple myeloma and mantle cell lymphoma....
9.
Hansson M, Behmer S, Ceder R, Mohammadi S, Preta G, Grafstrom R, et al.
PLoS One
. 2012 Oct;
7(9):e46001.
PMID: 23029358
Mastermind-like 1 (MAML1) is a transcriptional coregulator of activators in various signaling pathways, such as Notch, p53, myocyte enhancer factor 2C (MEF2C) and beta-catenin. In earlier studies, we demonstrated that...
10.
Rajarajan A, Stokes A, Bloor B, Ceder R, Desai H, Grafstrom R, et al.
PLoS One
. 2012 Jan;
7(1):e28776.
PMID: 22242150
Expression of CD44, a transmembrane hyaluronan-binding glycoprotein, is variably considered to have prognostic significance for different cancers, including oral squamous cell carcinoma. Although unclear at present, tissue-specific expression of particular...