Rohit V Pappu
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Explore the profile of Rohit V Pappu including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Qian D, Ausserwoger H, Sneideris T, Farag M, Pappu R, Knowles T
Proc Natl Acad Sci U S A
. 2024 Aug;
121(33):e2407453121.
PMID: 39102550
Phase separation in aqueous solutions of macromolecules underlies the generation of biomolecular condensates in cells. Condensates are membraneless bodies, representing dense, macromolecule-rich phases that coexist with the dilute, macromolecule-deficient phases....
12.
Guo X, Farag M, Qian N, Yu X, Ni A, Ma Y, et al.
bioRxiv
. 2024 Jul;
PMID: 39026887
We report the discovery that chemical reactions such as ATP hydrolysis can be catalyzed by condensates formed by intrinsically disordered proteins (IDPs), which themselves lack any intrinsic ability to function...
13.
Posey A, Bremer A, Erkamp N, Pant A, Knowles T, Dai Y, et al.
bioRxiv
. 2024 Jul;
PMID: 39005320
Biomolecular condensates form via processes that combine phase separation and reversible associations of multivalent macromolecules. Condensates can be two- or multi-phase systems defined by coexisting dense and dilute phases. Here,...
14.
Cohen S, Banerjee P, Pappu R
bioRxiv
. 2024 Jun;
PMID: 38915484
facsimiles of biomolecular condensates are formed by different types of intrinsically disordered proteins including prion-like low complexity domains (PLCDs). PLCD condensates are viscoelastic materials defined by time-dependent, sequence-specific complex shear...
15.
Kar M, Vogel L, Chauhan G, Felekyan S, Ausserwoger H, Welsh T, et al.
Nat Commun
. 2024 May;
15(1):4408.
PMID: 38782886
Phase separation and percolation contribute to phase transitions of multivalent macromolecules. Contributions of percolation are evident through the viscoelasticity of condensates and through the formation of heterogeneous distributions of nano-...
16.
Wang S, Gupta R, Benegal A, Avula R, Huang Y, Vahey M, et al.
ACS Sens
. 2024 May;
9(6):3096-3104.
PMID: 38753414
Lateral flow assays (LFAs) are currently the most popular point-of-care diagnostics, rapidly transforming disease diagnosis from expensive doctor checkups and laboratory-based tests to potential on-the-shelf commodities. Yet, their sensitive element,...
17.
Dar F, Cohen S, Mitrea D, Phillips A, Nagy G, Leite W, et al.
Nat Commun
. 2024 Apr;
15(1):3413.
PMID: 38649740
The functions of biomolecular condensates are thought to be influenced by their material properties, and these will be determined by the internal organization of molecules within condensates. However, structural characterizations...
18.
Lemke E, Babu M, Kriwacki R, Mittag T, Pappu R, Wright P, et al.
Mol Cell
. 2024 Apr;
84(7):1188-1190.
PMID: 38579677
In his commentary in this issue of Molecular Cell, Struhl reasons that the term "intrinsically disordered regions" represents a vague and confusing concept for protein function. However, the term "intrinsically...
19.
Qian D, Ausserwoger H, Sneideris T, Farag M, Pappu R, Knowles T
bioRxiv
. 2024 Apr;
PMID: 38562796
Phase separation in aqueous solutions of macromolecules is thought to underlie the generation of biomolecular condensates in cells. Condensates are membraneless bodies, representing dense, macromolecule-rich phases that coexist with the...
20.
King M, Ruff K, Lin A, Pant A, Farag M, Lalmansingh J, et al.
Cell
. 2024 Mar;
187(8):1889-1906.e24.
PMID: 38503281
Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks interspersed by E-rich regions, as defining features of nucleolar...