Roger S Chung
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Explore the profile of Roger S Chung including associated specialties, affiliations and a list of published articles.
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76
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1275
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Recent Articles
1.
Scherer N, Maurel C, Graus M, McAlary L, Richter G, Radford R, et al.
Nucleic Acids Res
. 2024 Feb;
52(9):5301-5319.
PMID: 38381071
Insoluble cytoplasmic aggregate formation of the RNA-binding protein TDP-43 is a major hallmark of neurodegenerative diseases including Amyotrophic Lateral Sclerosis. TDP-43 localizes predominantly in the nucleus, arranging itself into dynamic...
2.
San Gil R, Pascovici D, Venturato J, Brown-Wright H, Mehta P, Madrid San Martin L, et al.
Nat Commun
. 2024 Feb;
15(1):1508.
PMID: 38374041
Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic...
3.
Ragagnin A, Sundaramoorthy V, Farzana F, Gautam S, Saravanabavan S, Takalloo Z, et al.
Sci Rep
. 2023 Nov;
13(1):20467.
PMID: 37993492
Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD). Mutations in the CCNF gene, encoding cyclin F,...
4.
Babazadeh A, Rayner S, Lee A, Chung R
Ageing Res Rev
. 2023 Oct;
92:102085.
PMID: 37813308
A common feature of adult-onset neurodegenerative diseases is the presence of characteristic pathological accumulations of specific proteins. These pathological protein depositions can vary in their protein composition, cell-type distribution, and...
5.
Davidson J, Wu S, Rayner S, Cheng F, Duncan K, Russo C, et al.
Mol Neurobiol
. 2023 May;
60(9):5034-5054.
PMID: 37243816
Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis. CCNF encodes for cyclin F, which is part of the...
6.
Farrawell N, Bax M, McAlary L, McKenna J, Maksour S, Do-Ha D, et al.
Hum Mol Genet
. 2023 May;
32(14):2386-2398.
PMID: 37220877
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that share pathological features, including the aberrant accumulation of ubiquitinated protein inclusions within motor neurons. Previously, we have...
7.
Zou Y, Sun X, Wang Y, Yan C, Liu Y, Li J, et al.
Adv Mater
. 2023 Apr;
35(16):e2300777.
PMID: 37078222
No abstract available.
8.
van Hummel A, Sabale M, Przybyla M, van der Hoven J, Chan G, Feiten A, et al.
Neuropathol Appl Neurobiol
. 2023 Mar;
49(2):e12902.
PMID: 36951214
Aims: Amyotrophic lateral sclerosis (ALS) is characterised by a progressive loss of upper and lower motor neurons leading to muscle weakness and eventually death. Frontotemporal dementia (FTD) presents clinically with...
9.
Davidson J, Rayner S, Liu S, Cheng F, Ieva A, Chung R, et al.
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36901711
Proteomics offers vast potential for studying the molecular regulation of the human brain. Formalin fixation is a common method for preserving human tissue; however, it presents challenges for proteomic analysis....
10.
Vidal-Itriago A, Radford R, Aramideh J, Maurel C, Scherer N, Don E, et al.
Front Immunol
. 2022 Nov;
13:997786.
PMID: 36341385
Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central nervous system (CNS) during the early stages of embryonic development. After colonizing the CNS, they proliferate and remain...