Roger A Vaughan
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Explore the profile of Roger A Vaughan including associated specialties, affiliations and a list of published articles.
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61
Citations
720
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Recent Articles
1.
Wyatt E, VanDerStad L, Cook N, McGovern M, Zaman T, Lundin P, et al.
Cell Biochem Funct
. 2024 Sep;
42(7):e4117.
PMID: 39243192
Elevated circulating branched-chain amino acids (BCAA) have been linked with the severity of insulin resistance across numerous populations, implicating heightened BCAA metabolism as a potential therapy for insulin resistance. Recently,...
2.
VanDerStad L, Wyatt E, Vaughan R
Metabolites
. 2024 Jul;
14(7).
PMID: 39057712
Branched-chain amino acids (BCAA) are correlated with severity of insulin resistance, which may partially result from mitochondrial dysfunction. Mitochondrial dysfunction is also common during insulin resistance and is regulated in...
3.
Cook N, McGovern M, Zaman T, Lundin P, Vaughan R
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 38999929
Methods: C2C12 myotubes were treated with MHY1485 or DMSO control both with and without rapamycin. Gene expression was assessed using qRT-PCR and insulin sensitivity and protein expression by western blot....
4.
Cook N, McGovern M, Zaman T, Lundin P, Vaughan R
Nutrients
. 2024 Jun;
16(11).
PMID: 38892515
Methods: C2C12 mouse myoblasts were treated with fructose at a concentration of 100 µM (which approximates physiologically attainable concentrations in peripheral circulation) both with and without hyperinsulinemic-mediated insulin resistance. Gene...
5.
Escobar K, Vandusseldorp T, Johnson K, Stratton M, McCormick J, Moriarity T, et al.
Eur J Appl Physiol
. 2024 May;
124(10):2981-2992.
PMID: 38771358
Purpose: Autophagy and heat shock protein (HSP) response are proteostatic systems involved in the acute and adaptive responses to exercise. These systems may upregulate sequentially following cellular stress including acute...
6.
Rivera C, Smith C, Draper L, Kee M, Cook N, McGovern M, et al.
J Cell Biochem
. 2024 Jan;
125(3):e30520.
PMID: 38226684
Elevated circulating branched-chain amino acids (BCAAs) have been correlated with the severity of insulin resistance, leading to recent investigations that stimulate BCAA metabolism for the potential benefit of metabolic diseases....
7.
VanDerStad L, Wyatt E, Vaughan R
Diabet Med
. 2023 Dec;
41(5):e15271.
PMID: 38140911
Aims: Sodium-glucose cotransporter 2 (SGLT2) inhibitors such as canagliflozin (CANA) have emerged as an effective adjuvant therapy in the management of diabetes, however, past observations suggest CANA may alter skeletal...
8.
Rivera C, Smith C, Draper L, Watne R, Wommack A, Vaughan R
Biochimie
. 2023 Nov;
219:155-164.
PMID: 38008282
Type 2 diabetes is characterized by elevated circulating blood metabolites such as glucose, insulin, and branched chain amino acids (BCAA), which often coincide with reduced mitochondrial function. 4-Phenylbutyrate (PBA), an...
9.
Rivera C, Kamer M, Cook N, McGovern M, Watne R, Wommack A, et al.
Cell Biochem Funct
. 2023 Nov;
41(8):1422-1429.
PMID: 37916846
Type 2 diabetes is characterized by elevated blood glucose and reduced insulin sensitivity in target tissues. Moreover, reduced mitochondrial metabolism and expressional profile of genes governing mitochondrial metabolism (such as...
10.
Rivera C, Watne R, Wommack A, Vaughan R
Amino Acids
. 2023 Sep;
55(11):1701-1705.
PMID: 37740788
Insulin resistance is often accompanied by elevated circulating branched-chain amino acids (BCAA). We investigated the effects of insulin resistance on the mitochondrial BCAA transporter, SLC25A44, using a myotube model of...