Roelof Mol
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Explore the profile of Roelof Mol including associated specialties, affiliations and a list of published articles.
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20
Citations
91
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Recent Articles
1.
Groenendaal D, Strabach G, Garcia-Hernandez A, Kadokura T, Heeringa M, Mol R, et al.
Clin Pharmacol Drug Dev
. 2016 Apr;
3(3):194-201.
PMID: 27128609
We investigated the effects of ketoconazole on the pharmacokinetics (PK) of the direct clotting factor Xa inhibitor darexaban (YM150) and its main active metabolite darexaban glucuronide (YM-222714) which almost entirely...
2.
Gibbons J, de Vries M, Krauwinkel W, Ohtsu Y, Noukens J, van der Walt J, et al.
Clin Pharmacokinet
. 2015 May;
54(10):1057-69.
PMID: 25929560
Background And Objectives: Two phase I drug interaction studies were performed with oral enzalutamide, which is approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Methods: A parallel-treatment design...
3.
Bennett D, Gibbons J, Mol R, Ohtsu Y, Williard C
Bioanalysis
. 2013 Dec;
6(6):737-44.
PMID: 24328824
Background: Enzalutamide is an androgen receptor inhibitor that targets multiple steps in the androgen receptor signaling pathway. Oral enzalutamide was recently approved by the US FDA and health authorities in...
4.
Kadokura T, Kashiwa M, Groenendaal D, Heeringa M, Mol R, Verheggen F, et al.
Biopharm Drug Dispos
. 2013 Aug;
34(8):431-41.
PMID: 23929659
Background: Darexaban (YM150) is a potent direct factor Xa (FXa) inhibitor developed for the prophylaxis of venous and arterial thromboembolic disease. This drug is rapidly and extensively metabolized to darexaban...
5.
Kadokura T, Groenendaal D, Heeringa M, Mol R, Verheggen F, Garcia-Hernandez A, et al.
Eur J Drug Metab Pharmacokinet
. 2013 Jun;
39(1):1-9.
PMID: 23754514
To investigate the impact of the direct Factor Xa inhibitor darexaban administered in a modified-release formulation (darexaban-MR) on the pharmacokinetic (PK) profile of digoxin. In this Phase I, randomized, double-blind,...
6.
Groenendaal D, Strabach G, Garcia-Hernandez A, Kadokura T, Heeringa M, Mol R, et al.
Br J Clin Pharmacol
. 2012 May;
75(2):440-9.
PMID: 22642721
Aims: We investigated the effects of rifampicin on the pharmacokinetics (PK) of the direct clotting factor Xa inhibitor darexaban (YM150) and its main active metabolite, darexaban glucuronide (YM-222714), which almost...
7.
Servais A, Fillet M, Mol R, Rousseau A, Crommen J, Somsen G, et al.
Electrophoresis
. 2010 Mar;
31(7):1157-1161.
PMID: 20209573
The influence of the BGE composition, including the addition of a single-isomer sulfated beta-CD derivative, on the ionization performance of the model compound carvedilol in NACE-ESI-MS was studied using an...
8.
Somsen G, Mol R, de Jong G
J Chromatogr A
. 2010 Feb;
1217(25):3978-91.
PMID: 20181344
The use of pseudostationary phases (PSPs) in capillary electrophoresis provides powerful separation systems of high efficiency, selectivity and flexibility. Such electrokinetic chromatographic (EKC) systems are particularly useful for chiral analysis...
9.
Mol R, de Jong G, Somsen G
Electrophoresis
. 2008 Sep;
29(17):3575-81.
PMID: 18803218
The potential of nonaqueous electrokinetic chromatography (NAEKC) using cyclodextrins (CD) for the analysis of basic drugs and related compounds was evaluated. Both UV absorbance and mass spectrometric (MS) detection were...
10.
Mol R, de Jong G, Somsen G
Rapid Commun Mass Spectrom
. 2008 Feb;
22(6):790-6.
PMID: 18275093
Non-aqueous electrokinetic chromatography (NAEKC) using cationic cyclodextrins (CDs) was coupled to electrospray ionization mass spectrometry (ESI-MS). A methanolic background electrolyte (BGE) was used which contained the hydrochloride salts of the...