Roderick MacKinnon
Overview
Explore the profile of Roderick MacKinnon including associated specialties, affiliations and a list of published articles.
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110
Citations
14219
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Recent Articles
1.
Zhang Y, Mazal H, Mandala V, Perez-Mitta G, Sondoghdar V, Haselwandter C, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
122(1):e2421275121.
PMID: 39739811
This study shows that five membrane proteins-three GPCRs, an ion channel, and an enzyme-form self-clusters under natural expression levels in a cardiac-derived cell line. The cluster size distributions imply that...
2.
Zhang Y, MacKinnon R
Proc Natl Acad Sci U S A
. 2024 Dec;
122(1):e2421280121.
PMID: 39739805
We examine the role of higher-order transient structures (HOTS) in M2R regulation of GIRK channels. Electron microscopic membrane protein location maps show that both proteins form HOTS that exhibit a...
3.
Fu Z, MacKinnon R
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2409334121.
PMID: 38985763
In this study, we used cryoelectron microscopy to determine the structures of the Flotillin protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily, from cell-derived vesicles without...
4.
Perez-Mitta G, Sezgin Y, Wang W, MacKinnon R
Sci Adv
. 2024 Jun;
10(25):eado4722.
PMID: 38905330
Integral membrane proteins (IMPs) constitute a large fraction of organismal proteomes, playing fundamental roles in physiology and disease. Despite their importance, the mechanisms underlying dynamic features of IMPs, such as...
5.
Falzone M, MacKinnon R
Proc Natl Acad Sci U S A
. 2023 Nov;
120(48):e2315011120.
PMID: 37991948
() enzymes cleave phosphatidylinositol 4,5-bisphosphate ( producing and (diacylglycerol). modulates the function of many ion channels, while and regulate intracellular Ca levels and protein phosphorylation by protein kinase C, respectively....
6.
Falzone M, MacKinnon R
bioRxiv
. 2023 Sep;
PMID: 37693483
Significance Statement: For certain cellular signaling processes, the background activity of signaling enzymes must be minimal and stimulus-dependent activation robust. Nowhere is this truer than in signaling by , whose...
7.
Mandala V, MacKinnon R
Proc Natl Acad Sci U S A
. 2023 May;
120(21):e2301985120.
PMID: 37192161
Voltage-dependent ion channels underlie the propagation of action potentials and other forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate opening and closing of the...
8.
Falzone M, MacKinnon R
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2301121120.
PMID: 37172014
catalyze the hydrolysis of phosphatidylinositol 4, 5-bisphosphate [Formula: see text] into [Formula: see text] [Formula: see text] and [Formula: see text] [Formula: see text]. [Formula: see text] regulates the activity...
9.
Tao X, Zhao C, MacKinnon R
Proc Natl Acad Sci U S A
. 2023 Apr;
120(18):e2302325120.
PMID: 37098056
Integral membrane protein structure determination traditionally requires extraction from cell membranes using detergents or polymers. Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly...
10.
Perez-Mitta G, MacKinnon R
Proc Natl Acad Sci U S A
. 2023 Mar;
120(12):e2221541120.
PMID: 36913590
Mechanical forces modify the cell membrane potential by opening mechanosensitive ion channels. We report the design and construction of a lipid bilayer tensiometer to study channels that respond to lateral...