Robyn Mary Brown
Overview
Explore the profile of Robyn Mary Brown including associated specialties, affiliations and a list of published articles.
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9
Citations
230
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Recent Articles
1.
OShea M, Anversa R, Chng S, Campbell E, Walker L, Andrews Z, et al.
Biochem Pharmacol
. 2024 Nov;
230(Pt 2):116637.
PMID: 39561925
The insular cortex is a multifunctional and richly connected region of the cerebral cortex, critical in the neural integration of external stimuli and internal signals. Well-served for this role by...
2.
Poon S, Brown R, Sumithran P
Nutrients
. 2024 Sep;
16(17).
PMID: 39275308
Very low energy diets (VLEDs) contain <800 kcal/day and typically comprise formulated meal replacement products with adequate protein and micronutrients. Food-based VLEDs are an alternative approach, but it is uncertain...
3.
Brown R, Kupchik Y, Spencer S, Garcia-Keller C, Spanswick D, Lawrence A, et al.
Biol Psychiatry
. 2016 Feb;
81(9):797-806.
PMID: 26826876
Background: There is increasing evidence that the pathological overeating underlying some forms of obesity is compulsive in nature and therefore contains elements of an addictive disorder. However, direct physiological evidence...
4.
Brown R, Kim A, Khoo S, Kim J, Jupp B, Lawrence A
Addict Biol
. 2015 Apr;
21(3):603-12.
PMID: 25899624
Orexins (hypocretins) are hypothalamic neuropeptides that innervate the entire neuraxis, including the prelimbic cortex and ventral tegmental area and have been implicated in ethanol-seeking behaviour. The present study aimed to...
5.
Khoo S, Brown R
CNS Drugs
. 2014 Jun;
28(8):713-30.
PMID: 24942635
Addiction is a chronic relapsing disorder which presents a significant global health burden and unmet medical need. The orexin/hypocretin system is an attractive potential therapeutic target as demonstrated by the...
6.
Brown R, Khoo S, Lawrence A
Int J Neuropsychopharmacol
. 2013 Apr;
16(9):2067-79.
PMID: 23601187
Orexins are hypothalamic neuropeptides which bind to two G-protein-coupled receptors, orexin-1 (OX(1)R) and orexin-2 (OX(2)R) receptor. While a role for OX(1)R has been established in both ethanol reinforcement and ethanol-seeking...
7.
Brown R, Lawrence A
Curr Opin Neurobiol
. 2013 Mar;
23(4):467-72.
PMID: 23537903
Orexin (hypocretin) containing neurons reside in discrete regions of the lateral hypothalamus from where they innervate the entire neuroaxis. Via actions upon orexin receptors (OX1 and OX2), the orexin peptides...
8.
Brown R, Short J, Lawrence A
PLoS One
. 2011 Jan;
5(12):e15889.
PMID: 21209913
Relapse prevention represents the primary therapeutic challenge in the treatment of drug addiction. As with humans, drug-seeking behaviour can be precipitated in laboratory animals by exposure to a small dose...
9.
Brown R, Short J, Cowen M, Ledent C, Lawrence A
Neuropsychopharmacology
. 2008 Jun;
34(4):844-56.
PMID: 18536706
The adenosine A(2A) receptor is specifically enriched in the medium spiny neurons that make up the 'indirect' output pathway from the ventral striatum, a structure known to have a crucial,...