Robin H G A van den Biggelaar
Overview
Explore the profile of Robin H G A van den Biggelaar including associated specialties, affiliations and a list of published articles.
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12
Citations
164
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Recent Articles
1.
van den Biggelaar R, Walburg K, van den Eeden S, van Doorn C, Meiler E, de Ries A, et al.
Sci Rep
. 2024 Jul;
14(1):17225.
PMID: 39060313
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically...
2.
van der Klugt T, van den Biggelaar R, Saris A
Crit Rev Microbiol
. 2024 Jun;
:1-21.
PMID: 38916142
() is the causative pathogen of tuberculosis, the most lethal infectious disease resulting in 1.3 million deaths annually. Treatments against are increasingly impaired by the growing prevalence of antimicrobial drug...
3.
van den Biggelaar R, Walburg K, van den Eeden S, van Doorn C, Meiler E, de Ries A, et al.
Front Cell Infect Microbiol
. 2024 Apr;
14:1367938.
PMID: 38590439
The increasing prevalence of antimicrobial-resistant strains, especially methicillin-resistant (MRSA), poses a threat to successful antibiotic treatment. Unsuccessful attempts to develop a vaccine and rising resistance to last-resort antibiotics urge the...
4.
van den Biggelaar R, Hoefnagel M, Vandebriel R, Sloots A, Hendriksen C, van Eden W, et al.
Expert Rev Vaccines
. 2021 Sep;
20(10):1221-1233.
PMID: 34550041
Introduction: Before release, vaccine batches are assessed for quality to evaluate whether they meet the product specifications. Vaccine batch tests, in particular of inactivated and toxoid vaccines, still largely rely...
5.
Meijerink N, van den Biggelaar R, van Haarlem D, Stegeman J, Rutten V, Jansen C
Vet Res
. 2021 Aug;
52(1):109.
PMID: 34404469
Salmonella enterica serotype Enteritidis (SE) is a zoonotic pathogen which causes foodborne diseases in humans as well as severe disease symptoms in young chickens. More insight in innate and adaptive...
6.
van den Biggelaar R, van der Maas L, Meiring H, Pennings J, van Eden W, Rutten V, et al.
Sci Rep
. 2021 Jun;
11(1):12666.
PMID: 34135356
Inactivated poultry vaccines are subject to routine potency testing for batch release, requiring large numbers of animals. The replacement of in vivo tests for cell-based alternatives can be facilitated by...
7.
van den Biggelaar R, van Eden W, Rutten V, Jansen C
Vaccines (Basel)
. 2020 Nov;
8(4).
PMID: 33182624
High-quality vaccines are crucial to prevent infectious disease outbreaks in the poultry industry. In vivo vaccination tests are routinely used to test poultry vaccines for their potency, i.e., their capacity...
8.
Peng L, van den Biggelaar R, Jansen C, Haagsman H, Veldhuizen E
Immunobiology
. 2020 Nov;
225(6):152004.
PMID: 33130516
Macrophages are part of the first line of defense against invading pathogens. In mammals, the in vitro culture of macrophages from blood monocytes or bone marrow cells is well established,...
9.
Verwoolde M, van den Biggelaar R, van Baal J, Jansen C, Lammers A
Vet Sci
. 2020 Aug;
7(3).
PMID: 32825152
Beta-glucan-stimulated mammalian myeloid cells, such as macrophages, show an increased responsiveness to secondary stimulation in a nonspecific manner. This phenomenon is known as trained innate immunity and is important to...
10.
Verwoolde M, van den Biggelaar R, Reilingh G, Arts J, van Baal J, Lammers A, et al.
Dev Comp Immunol
. 2020 Aug;
114:103811.
PMID: 32750399
Recently, we have reported trained innate immunity in laying chicken monocytes. In the present study, we further investigated trained innate immunity of monocytes in layers and broilers. Monocytes of both...