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Roberto Frussa-Filho

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Articles 86
Citations 800
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Recent Articles
1.
Marinho E, Oliveira-Lima A, Reis H, Santos-Baldaia R, Wuo-Silva R, Hollais A, et al.
Front Pharmacol . 2023 Feb; 14:1100527. PMID: 36814501
The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of...
2.
Libarino-Santos M, de Santana Santos A, Cata-Preta E, Barros-Santos T, Nunes Brandao N, Borges A, et al.
Drug Alcohol Depend . 2020 Jan; 208:107856. PMID: 31954952
Background: Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated that...
3.
Wuo-Silva R, Fukushiro-Lopes D, Fialho B, Hollais A, Santos-Baldaia R, Marinho E, et al.
Front Pharmacol . 2019 Mar; 10:211. PMID: 30914950
Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil...
4.
Trombin T, Procopio-Souza R, Kameda S, Zanlorenci L, Fukushiro D, Calzavara M, et al.
Pharmacol Biochem Behav . 2018 Jul; 173:90-95. PMID: 30031027
Opioid addiction is a growing public health problem, being currently considered an epidemic in the United States. Investigating the behavioral effects of opioids and the factors influencing their development becomes...
5.
Berro L, Tufik S, Frussa-Filho R, Andersen M, Tufik S
Neurosci Lett . 2018 Feb; 671:29-32. PMID: 29421538
Sleep deprivation (SD) and amphetamine use are commonly associated conditions. SD shares similar neurobiological effects with psychostimulants, playing an important role in drug addiction, especially through conditioning manipulations. The aim...
6.
Marinho E, Oliveira-Lima A, Yokoyama T, Santos-Baldaia R, Ribeiro L, Baldaia M, et al.
Pharmacol Biochem Behav . 2017 Apr; 156:16-23. PMID: 28366798
CB1 receptor antagonists have been shown to prevent acute and long-term behavioral effects of cocaine. Here we evaluate the effectiveness of the CB1 receptor antagonist rimonabant to modify sensitized responses...
7.
Wuo-Silva R, Fukushiro D, Hollais A, Santos-Baldaia R, Mari-Kawamoto E, Berro L, et al.
Front Pharmacol . 2016 Nov; 7:420. PMID: 27872594
There is substantial controversy about the addictive potential of modafinil, a wake-promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due...
8.
Esteves A, Lopes C, Frank M, Arida R, Frussa-Filho R, Tufik S, et al.
Brain Res . 2016 Mar; 1639:47-57. PMID: 26923163
The purpose of the present study was to determine whether physical exercise (PE) has a protective effect in an experimental animal model of sleep-related movement disorder (A11 dopaminergic nuclei lesions...
9.
Oliveira de Almeida W, Esteves A, Leite de Almeida-Junior C, Lee K, Frank M, Mariano M, et al.
Sleep Sci . 2015 Oct; 7(4):203-8. PMID: 26483930
Long-term treatments with dopaminergic agents are associated with adverse effects, including augmentation. Augmentation consists of an exacerbation of restless legs syndrome (a sleep-related movement disorder) symptoms during treatment compared to...
10.
Borcoi A, Patti C, Zanin K, Hollais A, Santos-Baldaia R, Ceccon L, et al.
Prog Neuropsychopharmacol Biol Psychiatry . 2015 Jun; 63:63-9. PMID: 26051209
Background: Prenatal environmental adversities may affect brain development and are associated with increased risk for schizophrenia, an illness with 50% comorbidity with addiction. Maternal immune activation by poly-inosinic-citidilic acid (Poly(I:C))...