Robert W Siggins
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Explore the profile of Robert W Siggins including associated specialties, affiliations and a list of published articles.
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29
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836
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Recent Articles
1.
Deville P, Dennis J, Warren O, Fontenot C, Messa G, Carter J, et al.
J Burn Care Res
. 2025 Jan;
PMID: 39820680
Adipose-derived stem cells (ADSCs) have an important role in the modulation of burned tissue repair through the release of paracrine factors that stimulate the wound healing response. In this study,...
2.
Whitehead A, Wang Z, Boustany R, Vives R, Lazartigues E, Liu J, et al.
Matrix Biol
. 2024 Oct;
134:107-118.
PMID: 39368561
The heparan sulfate (HS) 6-O-endosulfatases or the Sulfs (Sulf1 and Sulf2) are the only known enzymes that can modify HS sulfation status extracellularly and have been shown to regulate diverse...
3.
Shi X, Simms K, Ewing T, Lin Y, Chen Y, Melvan J, et al.
Front Immunol
. 2024 Apr;
15:1368099.
PMID: 38665923
Early increase in the level of endothelial progenitor cells (EPCs) in the systemic circulation occurs in patients with septic infection/sepsis. The significance and underlying mechanisms of this response remain unclear....
4.
Siggins R, McTernan P, Simon L, Souza-Smith F, Molina P
Int J Mol Sci
. 2023 May;
24(10).
PMID: 37239997
Alcohol misuse, directly or indirectly as a result of its metabolism, negatively impacts most tissues, including four with critical roles in energy metabolism regulation: the liver, pancreas, adipose, and skeletal...
5.
Levitt D, Simon L, Lin H, Siggins R, Ferguson T, Molina P, et al.
Alcohol Clin Exp Res
. 2022 Sep;
46(11):2041-2053.
PMID: 36124866
Background: Antiretroviral therapy has improved life expectancy among people living with HIV (PLWH). Despite increased longevity, PLWH are at increased risk of age-related comorbidities, including frailty. We examined the relationship...
6.
McTernan P, Katz P, Porretta C, Welsh D, Siggins R
Biochem (Basel)
. 2022 Aug;
1(1):1-18.
PMID: 35937039
Intracellular reduction-oxidation (RedOx) status mediates a myriad of critical biological processes. Importantly, RedOx status regulates the differentiation of hematopoietic stem and progenitor cells (HSPCs), mesenchymal stromal cells (MSCs) and maturation...
7.
McTernan P, Siggins R, Catinis A, Amedee A, Simon L, Molina P
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883501
Effective antiretroviral therapy (ART) has transitioned HIV to a chronic disease, with more than 50% of people living with HIV (PLWH) being over the age of 50. HIV targets activated...
8.
McTernan P, Levitt D, Welsh D, Simon L, Siggins R, Molina P
Front Immunol
. 2022 May;
13:839390.
PMID: 35634279
CD4 T cell differentiation to pro-inflammatory and immunosuppressive subsets depends on immunometabolism. Pro-inflammatory CD4 subsets rely on glycolysis, while immunosuppressive Treg cells require functional mitochondria for their differentiation and function....
9.
Zifodya J, Ferguson T, Siggins R, Brashear M, Kantrow S, Nelson S, et al.
Alcohol
. 2022 Mar;
101:45-51.
PMID: 35306109
People living with HIV (PLWH) are at increased risk for noncommunicable diseases such as lung disease in part due to opportunistic infections including pneumonia. HIV infection is associated with increased...
10.
Gu M, Samuelson D, de la Rua N, Charles T, Taylor C, Luo M, et al.
Microbiol Immunol
. 2022 Jan;
66(6):330-341.
PMID: 35067963
The gut microbiota has a fundamental role in the development and the maturation of the host immune system. Both innate and adaptive immune cells have critical functions in microbial pathogen...