Robert W Old
Overview
Explore the profile of Robert W Old including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
106
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Recent Articles
1.
Wald N, Bestwick J, Lau K, Huttly W, Ke W, Cheng R, et al.
Clin Chim Acta
. 2019 Jun;
496:13-17.
PMID: 31211945
Background: A source of error in prenatal screening for trisomies is PCR amplification error associated with guanine-cytosine (GC) content of DNA fragments in maternal plasma. We describe a simple method...
2.
Wald N, Lau K, Bestwick J, Old R, Huttly W, Cheng R
Clin Chem
. 2018 Jun;
64(9):1394-1399.
PMID: 29945966
Background: An estimate of fetal fraction (FF) is needed for DNA-based screening for trisomy 21 and other aneuploidies, but there is no gold standard to validate FF measurement methods. We...
3.
Old R, Bestwick J, Wald N
F1000Res
. 2017 Nov;
6:1896.
PMID: 29167740
Prenatal cystic fibrosis (CF) screening is currently based on determining the carrier status of both parents. We propose a new method based only on the analysis of DNA in maternal...
4.
Crea F, Forman M, Hulme R, Old R, Ryan D, Mazey R, et al.
Fetal Diagn Ther
. 2017 Feb;
42(3):218-224.
PMID: 28171857
Objective: To develop a screening test for fetal trisomy 13, 18, and 21 using cell-free DNA from maternal blood with an automated workflow using the Ion Proton sequencing platform. Methods:...
5.
Abouna S, Old R, Pelengaris S, Epstein D, Ifandi V, Sweeney I, et al.
Organogenesis
. 2010 Oct;
6(2):125-33.
PMID: 20885859
Pregnancy is a normal physiological condition in which the maternal β-cell mass increases rapidly about two-fold to adapt to new metabolic challenges. We have used a lineage tracing of β-cells...
6.
Puszyk W, Crea F, Old R
Clin Biochem
. 2008 Dec;
42(7-8):736-8.
PMID: 19083998
Objectives: To assess whether different genomic cell-free DNAs are equally abundant in the plasma of individual donors, and any relationship between DNA methylation and representation in plasma. Design And Methods:...
7.
Puszyk W, Chatha K, Elsenheimer S, Crea F, Old R
Clin Chim Acta
. 2008 Nov;
400(1-2):107-10.
PMID: 19000666
Background: Genomic DNA sequences in cell-free plasma are biomarkers of cancer prognosis, where characteristic changes in methylation of tumour suppressor or oncogene DNA regions are indicative of changes in gene...
8.
Puszyk W, Crea F, Old R
Prenat Diagn
. 2007 Nov;
28(1):1-6.
PMID: 18022821
The discovery of cell-free fetal (cff) DNA and RNA in the maternal circulation has driven developments in noninvasive prenatal diagnosis (NIPD) for the past decade. Detection of paternally derived alleles...
9.
Old R, Crea F, Puszyk W, Hulten M
Reprod Biomed Online
. 2007 Aug;
15(2):227-35.
PMID: 17697502
This report describes the first identification and characterization of three chromosome-21-specific DNA sequences (and reference sequences from other chromosomes) that are differentially methylated between peripheral blood and placental tissue, with...
10.
Morgan A, Barrett J, Griffiths B, Subramanian D, Robinson J, Keyte V, et al.
Arthritis Res Ther
. 2005 Dec;
8(1):R5.
PMID: 16356189
The Fcgamma receptors play important roles in the initiation and regulation of many immunological and inflammatory processes, and genetic variants (FCGR) have been associated with numerous autoimmune and infectious diseases....