Robert van Domselaar
Overview
Explore the profile of Robert van Domselaar including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
307
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0
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Recent Articles
1.
Hajikhezri Z, Zygouras I, Sonnerborg A, van Domselaar R
Cell Death Discov
. 2025 Feb;
11(1):44.
PMID: 39905001
The persistence of HIV-1 latency reservoirs in CD4 T cells is a significant obstacle for curing HIV-1. Shock-and-kill strategies, which aim to reactivate latent HIV-1 followed by cytotoxic clearance, have...
2.
Cena-Diez R, Narayanan A, Ray S, van de Klundert M, Rodriguez J, Nilvebrant J, et al.
Int J Antimicrob Agents
. 2023 Mar;
61(5):106792.
PMID: 36931610
Background: Enhanced levels of a dipeptide, WG-am, have been reported among elite controllers - patients who spontaneously control their HIV-1 infection. This study aimed to evaluate anti-HIV-1 activity and mechanism...
3.
Furtado Milao J, Love L, Gourgi G, Derhaschnig L, Svensson J, Sonnerborg A, et al.
Front Immunol
. 2022 Dec;
13:1067767.
PMID: 36561752
The establishment of a latency reservoir is the major obstacle for a cure of HIV-1. The shock-and-kill strategy aims to reactivate HIV-1 replication in HIV -1 latently infected cells, exposing...
4.
Saccon E, Mikaeloff F, Figueras Ivern P, Vegvari A, Sonnerborg A, Neogi U, et al.
Front Immunol
. 2021 May;
12:669347.
PMID: 33953729
Untreated HIV-1 infection leads to a slow decrease in CD4 T cell lymphocytes over time resulting in increased susceptibility to opportunistic infections (acquired immunodeficiency syndrome, AIDS) and ultimately death of...
5.
Sperk M, van Domselaar R, Rodriguez J, Mikaeloff F, Vinhas B, Saccon E, et al.
J Proteome Res
. 2020 Oct;
19(11):4259-4274.
PMID: 33095583
Emerging and re-emerging infectious diseases due to RNA viruses cause major negative consequences for the quality of life, public health, and overall economic development. Most of the RNA viruses causing...
6.
van de Ven R, de Groot J, Park D, van Domselaar R, de Jong D, Szuhai K, et al.
Nat Commun
. 2019 Jul;
8:16030.
PMID: 31305775
[This corrects the article DOI: 10.1038/ncomms13874.].
7.
van Domselaar R, Njenda D, Rao R, Sonnerborg A, Singh K, Neogi U
J Virol
. 2019 Feb;
93(9).
PMID: 30760577
Human immunodeficiency virus type 1 subtype C (HIV-1C) has a natural deletion of a YPxL motif in its Gag-p6 late domain. This domain mediates the binding of Gag to host...
8.
Sperk M, van Domselaar R, Neogi U
Int J Mol Sci
. 2018 Jul;
19(7).
PMID: 29987244
Immune checkpoints are several co-stimulatory and inhibitory pathways that regulate T cell immune responses. Most of the discoveries about immune checkpoints were made in cancer research where inhibitory immune checkpoints...
9.
Zhang W, Ambikan A, Sperk M, van Domselaar R, Nowak P, Noyan K, et al.
EBioMedicine
. 2017 Dec;
27:40-50.
PMID: 29269040
A small subset of HIV-1 infected individuals, the "Elite Controllers" (EC), can control viral replication and restrain progression to immunodeficiency without antiretroviral therapy (ART). In this study, a cross-sectional transcriptomics...
10.
van de Ven R, de Groot J, Park D, van Domselaar R, de Jong D, Szuhai K, et al.
Nat Commun
. 2016 Dec;
7:13874.
PMID: 28004812
Spatiotemporal activation of RhoA and actomyosin contraction underpins cellular adhesion and division. Loss of cell-cell adhesion and chromosomal instability are cardinal events that drive tumour progression. Here, we show that...