Robert T Abraham
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Explore the profile of Robert T Abraham including associated specialties, affiliations and a list of published articles.
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102
Citations
8708
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Recent Articles
1.
Baltgalvis K, Lamb K, Symons K, Wu C, Hoffman M, Snead A, et al.
Nature
. 2024 Jul;
631(8021):E12.
PMID: 38961306
No abstract available.
2.
Baltgalvis K, Lamb K, Symons K, Wu C, Hoffman M, Snead A, et al.
Nature
. 2024 Apr;
629(8011):435-442.
PMID: 38658751
WRN helicase is a promising target for treatment of cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate in cells with...
3.
Park S, Pascua E, Lindquist K, Kimberlin C, Deng X, Mak Y, et al.
Nat Commun
. 2021 Jan;
12(1):710.
PMID: 33514714
Antibody-based therapeutics have experienced a rapid growth in recent years and are now utilized in various modalities spanning from conventional antibodies, antibody-drug conjugates, bispecific antibodies to chimeric antigen receptor (CAR)...
4.
Maskey R, Wang F, Lehman E, Wang Y, Emmanuel N, Zhong W, et al.
Cell Cycle
. 2020 Dec;
20(1):65-80.
PMID: 33356791
Palbociclib, a selective CDK4/6 kinase inhibitor, is approved in combination with endocrine therapies for the treatment of advanced estrogen receptor positive (ER+) breast cancer. In pre-clinical cancer models, CDK4/6 inhibitors...
5.
Arensman M, Yang X, Zhong W, Bisulco S, Upeslacis E, Rosfjord E, et al.
Oncoimmunology
. 2020 Sep;
9(1):1800162.
PMID: 32923161
Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it...
6.
7.
Arensman M, Yang X, Leahy D, Toral-Barza L, Mileski M, Rosfjord E, et al.
Proc Natl Acad Sci U S A
. 2019 Apr;
116(19):9533-9542.
PMID: 31019077
T cell-invigorating cancer immunotherapies have near-curative potential. However, their clinical benefit is currently limited, as only a fraction of patients respond, suggesting that these regimens may benefit from combination with...
8.
Fruman D, Chiu H, Hopkins B, Bagrodia S, Cantley L, Abraham R
Cell
. 2017 Aug;
170(4):605-635.
PMID: 28802037
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested...
9.
Emmanuel N, Ragunathan S, Shan Q, Wang F, Giannakou A, Huser N, et al.
Cell Rep
. 2017 Jun;
19(13):2665-2680.
PMID: 28658616
Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine...
10.
Ihle N, Abraham R
Mol Cell
. 2017 Mar;
65(6):959-960.
PMID: 28306509
The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson's disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression...