» Authors » Robert S Harris

Robert S Harris

Explore the profile of Robert S Harris including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 39
Citations 4031
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
11.
Guiblet W, Cremona M, Harris R, Chen D, Eckert K, Chiaromonte F, et al.
Nucleic Acids Res . 2021 Jan; 49(3):1497-1516. PMID: 33450015
Approximately 13% of the human genome can fold into non-canonical (non-B) DNA structures (e.g. G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular processes. Non-B DNA also hinders replication,...
12.
Armstrong J, Hickey G, Diekhans M, Fiddes I, Novak A, Deran A, et al.
Nature . 2020 Nov; 587(7833):246-251. PMID: 33177663
New genome assemblies have been arriving at a rapidly increasing pace, thanks to decreases in sequencing costs and improvements in third-generation sequencing technologies. For example, the number of vertebrate genome...
13.
Cechova M, Vegesna R, Tomaszkiewicz M, Harris R, Chen D, Rangavittal S, et al.
Proc Natl Acad Sci U S A . 2020 Oct; 117(42):26273-26280. PMID: 33020265
The mammalian male-specific Y chromosome plays a critical role in sex determination and male fertility. However, because of its repetitive and haploid nature, it is frequently absent from genome assemblies...
14.
Harris R, Medvedev P
Bioinformatics . 2019 Sep; 36(3):721-727. PMID: 31504157
Motivation: Algorithmic solutions to index and search biological databases are a fundamental part of bioinformatics, providing underlying components to many end-user tools. Inexpensive next generation sequencing has filled publicly available...
15.
Harris R, Cechova M, Makova K
Bioinformatics . 2019 Jul; 35(22):4809-4811. PMID: 31290946
Summary: Tandem DNA repeats can be sequenced with long-read technologies, but cannot be accurately deciphered due to the lack of computational tools taking high error rates of these technologies into...
16.
Cechova M, Harris R, Tomaszkiewicz M, Arbeithuber B, Chiaromonte F, Makova K
Mol Biol Evol . 2019 Jul; 36(11):2415-2431. PMID: 31273383
Satellite repeats are a structural component of centromeres and telomeres, and in some instances, their divergence is known to drive speciation. Due to their highly repetitive nature, satellite sequences have...
17.
Li W, Yang L, Harris R, Lin L, Olson T, Hamele C, et al.
BMC Med Genomics . 2019 Jun; 12(1):88. PMID: 31208405
Background: Large granular lymphocyte (LGL) leukemia is an uncommon cancer characterized by sustained clonal proliferation of LGL cells. Antibodies reactive to retroviruses have been documented in the serum of patients...
18.
Osorio-Valencia J, Wongviriyawong C, Winkler T, Kelly V, Harris R, Venegas J
PLoS One . 2018 Dec; 13(12):e0208337. PMID: 30566496
Background: Asthma exacerbations cause lung hyperinflation, elevation in load to inspiratory muscles, and decreased breathing capacity that, in severe cases, may lead to inspiratory muscle fatigue and respiratory failure. Hyperinflation...
19.
Guiblet W, Cremona M, Cechova M, Harris R, Kejnovska I, Kejnovsky E, et al.
Genome Res . 2018 Nov; 28(12):1767-1778. PMID: 30401733
DNA conformation may deviate from the classical B-form in ∼13% of the human genome. Non-B DNA regulates many cellular processes; however, its effects on DNA polymerization speed and accuracy have...
20.
Kohli P, Staziaki P, Janjua S, Addison D, Hallett T, Hennessy O, et al.
PLoS One . 2018 Jul; 13(7):e0201376. PMID: 30059544
Heart Failure (HF) and chronic obstructive pulmonary disease (COPD) are morbid diseases that often coexist. In patients with coexisting disease, COPD is an independent risk factor for readmission and mortality....