Robert M Witwicki
Overview
Explore the profile of Robert M Witwicki including associated specialties, affiliations and a list of published articles.
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9
Citations
1046
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0
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Recent Articles
1.
Hoxha S, Shepard A, Troutman S, Diao H, Doherty J, Janiszewska M, et al.
Cancer Res
. 2020 May;
80(12):2512-2522.
PMID: 32409309
The Hippo pathway regulates cell proliferation and organ size through control of the transcriptional regulators YAP (yes-associated protein) and TAZ. Upon extracellular stimuli such as cell-cell contact, the pathway negatively...
2.
Witwicki R, Ekram M, Qiu X, Janiszewska M, Shu S, Kwon M, et al.
Cell Rep
. 2018 Nov;
25(5):1255-1267.e5.
PMID: 30380416
Perturbed epigenomic programs play key roles in tumorigenesis, and chromatin modulators are candidate therapeutic targets in various human cancer types. To define singular and shared dependencies on DNA and histone...
3.
Shu S, Lin C, He H, Witwicki R, Tabassum D, Roberts J, et al.
Nature
. 2016 Jan;
529(7586):413-417.
PMID: 26735014
Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. BET bromodomain inhibitors, which have shown efficacy in several models of cancer,...
4.
Waszak S, Delaneau O, Gschwind A, Kilpinen H, Raghav S, Witwicki R, et al.
Cell
. 2015 Aug;
162(5):1039-50.
PMID: 26300124
Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription...
5.
Gheldof N, Witwicki R, Migliavacca E, Leleu M, Didelot G, Harewood L, et al.
PLoS One
. 2013 Nov;
8(11):e79973.
PMID: 24265791
Geo Series Accession Number: GSE33784, GSE33867.
6.
Waszak S, Kilpinen H, Gschwind A, Orioli A, Raghav S, Witwicki R, et al.
Bioinformatics
. 2013 Nov;
30(2):165-71.
PMID: 24255646
Motivation: High-throughput sequencing technologies enable the genome-wide analysis of the impact of genetic variation on molecular phenotypes at unprecedented resolution. However, although powerful, these technologies can also introduce unexpected artifacts....
7.
Kilpinen H, Waszak S, Gschwind A, Raghav S, Witwicki R, Orioli A, et al.
Science
. 2013 Oct;
342(6159):744-7.
PMID: 24136355
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between...
8.
Jacquemont S, Reymond A, Zufferey F, Harewood L, Walters R, Kutalik Z, et al.
Nature
. 2011 Sep;
478(7367):97-102.
PMID: 21881559
Both obesity and being underweight have been associated with increased mortality. Underweight, defined as a body mass index (BMI) ≤ 18.5 kg per m(2) in adults and ≤ -2 standard...
9.
Kloosterman T, Witwicki R, van der Kooi-Pol M, Bijlsma J, Kuipers O
J Bacteriol
. 2008 Jun;
190(15):5382-93.
PMID: 18515418
Homeostasis of Zn(2+) and Mn(2+) is important for the physiology and virulence of the human pathogen Streptococcus pneumoniae. Here, transcriptome analysis was used to determine the response of S. pneumoniae...