Robert L J Graham
Overview
Explore the profile of Robert L J Graham including associated specialties, affiliations and a list of published articles.
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27
Citations
1150
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Recent Articles
11.
Jang K, Sweredoski M, Graham R, Hess S, Clemons Jr W
J Proteomics
. 2014 Jan;
98:90-8.
PMID: 24382552
Biological Significance: This work demonstrates the importance of understanding vesicular proteomes from a human pathogen Campylobacter jejuni. From the secreted outer membrane vesicles (OMVs) of C. jejuni NCTC11168, we found...
12.
Mahdavi A, Szychowski J, Ngo J, Sweredoski M, Graham R, Hess S, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
111(1):433-8.
PMID: 24347637
Pathogenic microbes have evolved complex secretion systems to deliver virulence factors into host cells. Identification of these factors is critical for understanding the infection process. We report a powerful and...
13.
Kolawa N, Sweredoski M, Graham R, Oania R, Hess S, Deshaies R
Mol Cell Proteomics
. 2013 Jun;
12(10):2791-803.
PMID: 23793018
Yeast Cdc48 (p97/VCP in human cells) is a hexameric AAA ATPase that is thought to use ATP hydrolysis to power the segregation of ubiquitin-conjugated proteins from tightly bound partners. Current...
14.
Pierce N, Lee J, Liu X, Sweredoski M, Graham R, Larimore E, et al.
Cell
. 2013 Mar;
153(1):206-15.
PMID: 23453757
The modular SCF (Skp1, cullin, and F box) ubiquitin ligases feature a large family of F box protein substrate receptors that enable recognition of diverse targets. However, how the repertoire...
15.
Malerod H, Graham R, Sweredoski M, Hess S
J Proteome Res
. 2012 Dec;
12(1):248-59.
PMID: 23205564
The adenocarcinoma cell line HeLa serves as a model system for cancer research in general and cervical cancer in particular. In this study, hydrazide enrichment in combination with state-of-the art...
16.
Sohn C, Agnew H, Lee J, Sweredoski M, Graham R, Smith G, et al.
Anal Chem
. 2012 Feb;
84(6):2662-9.
PMID: 22339618
We present novel homobifunctional amine-reactive clickable cross-linkers (CXLs) for investigation of three-dimensional protein structures and protein-protein interactions (PPIs). CXLs afford consolidated advantages not previously available in a simple cross-linker, including...
17.
Haines D, Lee J, Beauparlant S, Kyle D, den Besten W, Sweredoski M, et al.
Mol Cell Proteomics
. 2012 Feb;
11(6):M111.016444.
PMID: 22337587
UBXD1 is a member of the poorly understood subfamily of p97 adaptors that do not harbor a ubiquitin association domain or bind ubiquitin-modified proteins. Of clinical importance, p97 mutants found...
18.
Sohn C, Lee J, Sweredoski M, Graham R, Smith G, Hess S, et al.
J Am Chem Soc
. 2012 Jan;
134(5):2672-80.
PMID: 22225568
We report the development of novel reagents for cell-level protein quantification, referred to as Caltech isobaric tags (CITs), which offer several advantages in comparison with other isobaric tags (e.g., iTRAQ...
19.
Sweredoski M, Smith G, Kalli A, Graham R, Hess S
J Biomol Tech
. 2011 Dec;
22(4):122-6.
PMID: 22131886
Visualization tools that allow both optimization of instrument's parameters for data acquisition and specific quality control (QC) for a given sample prior to time-consuming database searches have been scarce until...
20.
Zhang D, Sweredoski M, Graham R, Hess S, Shan S
Mol Cell Proteomics
. 2011 Oct;
11(2):M111.011585.
PMID: 22030350
The signal recognition particle (SRP), which mediates cotranslational protein targeting to cellular membranes, is universally conserved and essential for bacterial and mammalian cells. However, the current understanding of the role...