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Robert Kwiecien

Explore the profile of Robert Kwiecien including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 40
Citations 637
Followers 0
Related Specialties
Oncology
Neurology
General Medicine
Top 10 Co-Authors
Torsten Pietsch
Stefan Rutkowski
Andre O von Bueren
Katja von Hoff
Monika Warmuth-Metz
Martin Mynarek
Martin Benesch
Nicolas U Gerber
Carsten Friedrich
Brigitte Bison
Published In
Neuro Oncol
Eur J Cancer
PLoS One
Cancers (Basel)
J Perinat Med
Affiliations
Soon will be listed here.
Recent Articles
1.
MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma
Friker L, Perwein T, Waha A, Dorner E, Klein R, Blattner-Johnson M, et al.
Acta Neuropathol . 2025 Feb; 149(1):11. PMID: 39894875
Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pathogenic germline variants in the DNA mismatch repair (MMR) genes MSH2, MSH6, MLH1, and PMS2....
2.
Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype
Tauziede-Espariat A, Friker L, Nussbaumer G, Bison B, Dangouloff-Ros V, Metais A, et al.
Acta Neuropathol Commun . 2024 Nov; 12(1):176. PMID: 39558399
Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/B have not been comprehensively...
3.
Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
Nussbaumer G, Benesch M, Grabovska Y, Mackay A, Castel D, Grill J, et al.
Neuro Oncol . 2024 May; 26(9):1723-1737. PMID: 38717379
Background: The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established. Methods: We conducted a multinational retrospective study...
4.
Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies
Debring B, Mollers M, Koster H, Kwiecien R, Braun J, Oelmeier K, et al.
J Perinat Med . 2022 Aug; 51(3):328-336. PMID: 35969418
Objectives: The aim of this study was to assess the value of cervical strain elastography and Cervical Sliding Sign (CSS) for predicting spontaneous preterm birth (sPTB). Methods: In our case-control...
5.
Sentinel fall presenting to the emergency department (SeFallED) - protocol of a complex study including long-term observation of functional trajectories after a fall, exploration of specific fall risk factors, and patients' views on falls prevention
Stuckenschneider T, Koschate J, Dunker E, Reeck N, Hackbarth M, Hellmers S, et al.
BMC Geriatr . 2022 Jul; 22(1):594. PMID: 35850739
Background: Falls are a leading cause for emergency department (ED) visits in older adults. As a fall is associated with a high risk of functional decline and further falls and...
6.
Pediatric high-grade gliomas and the WHO CNS Tumor Classification-Perspectives of pediatric neuro-oncologists and neuropathologists in light of recent updates
Gielen G, Baugh J, van Vuurden D, Veldhuijzen van Zanten S, Hargrave D, Massimino M, et al.
Neurooncol Adv . 2022 Jun; 4(1):vdac077. PMID: 35733513
Background: The WHO Classification of Tumors of the Central Nervous System has undergone major restructuring. Molecularly defined diagnostic criteria were introduced in 2016 (revised 4th edition) and expanded in 2021...
7.
Clinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies
Obrecht D, Mynarek M, Hagel C, Kwiecien R, Spohn M, Bockmayr M, et al.
J Neurooncol . 2022 Feb; 157(1):37-48. PMID: 35190934
Purpose: To evaluate the clinical impact of isolated spread of medulloblastoma cells into cerebrospinal fluid without additional macroscopic metastases (M1-only). Methods: The HIT-MED database was searched for pediatric patients with...
8.
Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study
Gaab C, Adolph J, Tippelt S, Mikasch R, Obrecht D, Mynarek M, et al.
Cancers (Basel) . 2022 Feb; 14(3). PMID: 35158738
Recurrent medulloblastomas are associated with survival rates <10%. Adequate multimodal therapy is being discussed as having a major impact on survival. In this study, 93 patients with recurrent medulloblastoma treated...
9.
Refining M1 stage in medulloblastoma: criteria for cerebrospinal fluid cytology and implications for improved risk stratification from the HIT-2000 trial
Hagel C, Sloman V, Mynarek M, Petrasch K, Obrecht D, Kuhl J, et al.
Eur J Cancer . 2022 Feb; 164:30-38. PMID: 35151105
Background: Medulloblastoma is the most common malignant paediatric brain tumour, and cerebrospinal fluid (CSF) dissemination (M1 stage) is a high-risk prognostic factor. Criteria for CSF evaluation and for differentiating M0...
10.
SIOP PNET5 MB Trial: History and Concept of a Molecularly Stratified Clinical Trial of Risk-Adapted Therapies for Standard-Risk Medulloblastoma
Mynarek M, Milde T, Padovani L, Janssens G, Kwiecien R, Mosseri V, et al.
Cancers (Basel) . 2021 Dec; 13(23). PMID: 34885186
Background: SIOP PNET5 MB was initiated in 2014 as the first European trial using clinical, histological, and molecular parameters to stratify treatments for children and adolescents with standard-risk medulloblastoma. Methods:...