Robert J Tombari
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Explore the profile of Robert J Tombari including associated specialties, affiliations and a list of published articles.
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10
Citations
307
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Recent Articles
1.
Warren H, Saeger H, Tombari R, Chytil M, Rasmussen K, Olson D
J Med Chem
. 2024 Apr;
67(9):6922-6937.
PMID: 38648167
Tauopathy, neuronal atrophy, and psychological impairments are hallmarks of neurodegenerative diseases, such as Alzheimer's disease, that currently lack efficacious clinical treatments capable of rectifying these issues. To address these unmet...
2.
Vargas M, Dunlap L, Dong C, Carter S, Tombari R, Jami S, et al.
Science
. 2023 Feb;
379(6633):700-706.
PMID: 36795823
Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and...
3.
Tombari R, Mundy P, Morales K, Dunlap L, Olson D, Lein P
ACS Chem Neurosci
. 2023 Feb;
14(5):875-884.
PMID: 36753397
In recent years, psychedelics have garnered significant interest as therapeutic agents for treating diverse neuropsychiatric disorders. However, the potential for these compounds to produce developmental neurotoxicity has not been rigorously...
4.
Tombari R, Tuck J, Yardeny N, Gingrich P, Tantillo D, Olson D
Org Biomol Chem
. 2021 Sep;
19(35):7575-7580.
PMID: 34524347
Azobenzenes are widely used as dyes and photochromic compounds, with the Baeyer-Mills reaction serving as the most common method for their preparation. This transformation is often plagued by low yields...
5.
Tuck J, Tombari R, Yardeny N, Olson D
Org Lett
. 2021 May;
23(11):4305-4310.
PMID: 34019429
Azoheteroarenes make up an emerging class of photoswitchable compounds with unique photophysical properties and advantages over traditional azobenzenes. Therefore, methods for synthesizing azoheteroarenes are highly desirable. Here, we utilize azide-alkyne...
6.
Cameron L, Tombari R, Lu J, Pell A, Hurley Z, Ehinger Y, et al.
Nature
. 2020 Dec;
589(7842):474-479.
PMID: 33299186
The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals. Unlike most medications for the treatment of substance use disorders, anecdotal reports suggest that ibogaine has the potential...
7.
Dunlap L, Azinfar A, Ly C, Cameron L, Viswanathan J, Tombari R, et al.
J Med Chem
. 2020 Jan;
63(3):1142-1155.
PMID: 31977208
Ketamine, ,-dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth. Here, we report the first-ever structure-activity relationship study with the...
8.
Tsui K, Tombari R, Olson D, Tantillo D
J Nat Prod
. 2019 Dec;
82(12):3464-3468.
PMID: 31840986
Serlyticin-A is a secondary metabolite first isolated from a culture of grown using squid pen as the sole carbon/nitrogen source. A previous study by Kuo et al. demonstrated that it...
9.
Zhu J, Larach J, Tombari R, Gingrich P, Bode S, Tuck J, et al.
Org Lett
. 2019 Oct;
21(21):8765-8770.
PMID: 31638403
Photoswitches capable of accessing two geometric states are highly desirable, especially if their design is modular and incorporates a pharmacophore tethering site. We describe a redox isomerization strategy for synthesizing...
10.
Tombari R, Saunders C, Wu C, Dunlap L, Tantillo D, Olson D
ACS Chem Biol
. 2019 Aug;
14(9):1866-1873.
PMID: 31449387
Tryptophan, an essential amino acid, is metabolized into a variety of small molecules capable of impacting human physiology, and aberrant tryptophan metabolism has been linked to a number of diseases....