Robert H Squires
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Explore the profile of Robert H Squires including associated specialties, affiliations and a list of published articles.
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94
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1583
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Recent Articles
1.
Miethke A, Moukarzel A, Porta G, Covarrubias Esquer J, Czubkowski P, Ordonez F, et al.
Lancet Gastroenterol Hepatol
. 2024 May;
9(7):620-631.
PMID: 38723644
Background: Progressive familial intrahepatic cholestasis (PFIC) is a group of autosomal recessive disorders, the most prevalent being BSEP deficiency, resulting in disrupted bile formation, cholestasis, and pruritus. Building on a...
2.
Li R, Wang J, Zhang C, Squires J, Belle S, Ning J, et al.
J Pediatr Gastroenterol Nutr
. 2024 Feb;
78(2):320-327.
PMID: 38374548
Objectives: To develop and validate a prediction tool for pediatric acute liver failure (PALF) mortality risks that captures the rapid and heterogeneous clinical course for accurate and updated prediction. Methods:...
3.
Teckman J, Rosenthal P, Ignacio R, Spino C, Bass L, Horslen S, et al.
Hepatol Commun
. 2023 Dec;
7(12).
PMID: 38055647
Background: Our objective was to better understand the natural history and disease modifiers of Alpha-1-antitrypsin deficiency (AATD), a common genetic liver disease causing hepatitis and cirrhosis in adults and children....
4.
Squires J, Miethke A, Valencia C, Hawthorne K, Henn L, Van Hove J, et al.
Hepatol Commun
. 2023 May;
7(6).
PMID: 37184518
Background: Alterations in both mitochondrial DNA (mtDNA) and nuclear DNA genes affect mitochondria function, causing a range of liver-based conditions termed mitochondrial hepatopathies (MH), which are subcategorized as mtDNA depletion,...
5.
Gonzalez-Peralta R, Wirth S, Squires R, Mutschler F, Lang T, Pawlowska M, et al.
Hepatol Commun
. 2023 Feb;
7(3):e0031.
PMID: 36790337
Background: Approximately 3.5 million children and adolescents worldwide are chronically infected with HCV. This study uses pharmacokinetic modeling to identify pediatric doses of elbasvir/grazoprevir (EBR/GZR) that achieve plasma concentrations similar...
6.
Zhang C, Ning J, Belle S, Squires R, Cai J, Li R
J R Stat Soc Ser C Appl Stat
. 2022 Dec;
71(5):1137-1157.
PMID: 36466585
In medical studies, some therapeutic decisions could lead to dependent censoring for the survival outcome of interest. This is exemplified by a study of paediatric acute liver failure, where death...
7.
Shneider B, Spino C, Kamath B, Magee J, Ignacio R, Huang S, et al.
Hepatol Commun
. 2022 Jun;
6(8):1922-1933.
PMID: 35672955
There is growing interest in, but limited data about, intestinal bile acid transport inhibitors as treatment for cholestatic liver disease. The current analyses combine two similar randomized placebo-controlled trials with...
8.
Loomes K, Squires R, Kelly D, Rajwal S, Soufi N, Lachaux A, et al.
Hepatol Commun
. 2022 May;
6(9):2379-2390.
PMID: 35507739
Children with progressive familial intrahepatic cholestasis, including bile salt export pump (BSEP) and familial intrahepatic cholestasis-associated protein 1 (FIC1) deficiencies, suffer debilitating cholestatic pruritus that adversely affects growth and quality...
9.
Shneider B, Kamath B, Magee J, Goodrich N, Loomes K, Ye W, et al.
Hepatol Commun
. 2022 May;
6(8):1910-1921.
PMID: 35506349
The conduct of long-term conventional randomized clinical trials in rare diseases is very difficult, making evidenced-based drug development problematic. As a result, real-world data/evidence are being used more frequently to...
10.
Bass L, Ye W, Hawthorne K, Leung D, Murray K, Molleston J, et al.
Hepatology
. 2022 Mar;
76(3):712-726.
PMID: 35271743
Background And Aims: The natural history of gastroesophageal variceal hemorrhage (VH) in biliary atresia (BA) is not well characterized. We analyzed risk factors, incidence, and outcomes of VH in a...