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Robert Eckl

Explore the profile of Robert Eckl including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 133
Followers 0
Related Specialties
Chemistry
Science
Top 10 Co-Authors
Sibylle Hess
Carina M Sonnleitner
Isabell Seitz
Oliver Reiser
Henk Schulz
Ilka Ott
Albert Schomig
Hironori Edamatsu
Glenn E Dale
Daniel Schmidhuber
Published In
Arterioscler Thromb Vasc Biol
Proc Natl Acad Sci U S A
Angew Chem Int Ed Engl
J Med Chem
ACS Org Inorg Au
Affiliations
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Recent Articles
1.
Stereoselective Synthesis of Biologically Relevant Tetrahydropyridines and Dihydro-2-pyrans via Ring-Expansion of Monocyclopropanated Heterocycles
Eckl R, Fischer S, Sonnleitner C, Schmidhuber D, Rehbein J, Reiser O
ACS Org Inorg Au . 2023 Mar; 2(2):169-174. PMID: 36855453
A stereoselective, scalable, and metal-free ring-expansion of monocyclopropanated pyrroles and furans has been developed, leading to value-added highly functionalized tetrahydropyridine and dihydro-2-pyran derivatives. Featuring a cyclopropylcarbinyl cation rearrangement as the...
2.
Stereoselective Synthesis of Tropanes via a 6π-Electrocyclic Ring-Opening/ Huisgen [3+2]-Cycloaddition Cascade of Monocyclopropanated Heterocycles
Sonnleitner C, Park S, Eckl R, Ertl T, Reiser O
Angew Chem Int Ed Engl . 2020 Jul; 59(41):18110-18115. PMID: 32627302
The synthesis of tropanes via a microwave-assisted, stereoselective 6π-electrocyclic ring-opening/ Huisgen [3+2]-cycloaddition cascade of cyclopropanated pyrrole and furan derivatives with electron-deficient dipolarophiles is demonstrated. Starting from furans or pyrroles, 8-aza-...
3.
Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis
Seitz I, Hess S, Schulz H, Eckl R, Busch G, Montens H, et al.
Arterioscler Thromb Vasc Biol . 2007 Jan; 27(4):769-75. PMID: 17255532
Objective: The serine protease MT-SP1/matriptase plays an important role in cell migration and matrix degradation. Hepatocyte growth factor (HGF), urokinase-type plasminogen activator (uPA), and protease-activated receptor 2 (PAR-2) have been...
4.
Coagulation factor Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes: implications in acute myocardial infarction
Busch G, Seitz I, Steppich B, Hess S, Eckl R, Schomig A, et al.
Arterioscler Thromb Vasc Biol . 2004 Nov; 25(2):461-6. PMID: 15550696
Objective: In acute myocardial infarction (AMI), proinflammatory plasma C-reactive protein values are strongly associated with postinfarction morbidity and mortality. So far, the cause of these inflammatory changes is not well...
5.
Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate
Douangamath A, Dale G, DArcy A, Almstetter M, Eckl R, Frutos-Hoener A, et al.
J Med Chem . 2004 Mar; 47(6):1325-8. PMID: 14998322
High-resolution crystal structures of Staphylococcus aureus methionine aminopeptidase I in complex with various keto heterocycles and aminoketones were determined, and the intermolecular ligand interactions with the enzyme are reported. The...
6.
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
Kato-Stankiewicz J, Hakimi I, Zhi G, Zhang J, Serebriiskii I, Guo L, et al.
Proc Natl Acad Sci U S A . 2002 Oct; 99(22):14398-403. PMID: 12391290
The interaction of activated Ras with Raf initiates signaling cascades that contribute to a significant percentage of human tumors, suggesting that agents that specifically disrupt this interaction might have desirable...