Robert E Thompson
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Explore the profile of Robert E Thompson including associated specialties, affiliations and a list of published articles.
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22
Citations
609
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Recent Articles
1.
Zheng Q, Weekley B, Vinson D, Zhao S, Bastle R, Thompson R, et al.
Nature
. 2025 Jan;
637(8047):974-982.
PMID: 39779849
Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression. We previously demonstrated that serotonylation and dopaminylation of...
2.
Stewart A, Fulton S, Durand-de Cuttoli R, Thompson R, Chen P, Brindley E, et al.
bioRxiv
. 2024 Sep;
PMID: 39345578
Protein monoaminylation is a class of posttranslational modification (PTM) that contributes to transcription, physiology and behavior. While recent analyses have focused on histones as critical substrates of monoaminylation, the broader...
3.
Hua Y, Tay N, Ye X, Owen J, Liu H, Thompson R, et al.
bioRxiv
. 2024 Jun;
PMID: 38895383
Protein engineering through the chemical or enzymatic ligation of polypeptide fragments has proven enormously powerful for studying countless biochemical processes . In general, this strategy necessitates a protein folding step...
4.
Lukasak B, Thompson R, Mitchener M, Feng V, Bagert J, Muir T
ACS Cent Sci
. 2022 Mar;
8(2):176-183.
PMID: 35233450
Nucleosomes frequently exist as asymmetric species in native chromatin contexts. Current methods for the traceless generation of these heterotypic chromatin substrates are inefficient and/or difficult to implement. Here, we report...
5.
Zhao S, Chuh K, Zhang B, Dul B, Thompson R, Farrelly L, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(6).
PMID: 33526675
Serotonylation of glutamine 5 on histone H3 (H3Q5ser) was recently identified as a permissive posttranslational modification that coexists with adjacent lysine 4 trimethylation (H3K4me3). While the resulting dual modification, H3K4me3Q5ser,...
6.
Thompson R, Muir T
Chem Rev
. 2019 Nov;
120(6):3051-3126.
PMID: 31774265
Protein semisynthesis-defined herein as the assembly of a protein from a combination of synthetic and recombinant fragments-is a burgeoning field of chemical biology that has impacted many areas in the...
7.
Thompson R, Stevens A, Muir T
Nat Chem
. 2019 Jul;
11(8):737-743.
PMID: 31263208
Semisynthetic proteins engineered to contain non-coded elements such as post-translational modifications (PTMs) represent a powerful class of tools for interrogating biological processes. Here, we introduce a one-pot, chemoenzymatic method that...
8.
Beh L, Debelouchina G, Clay D, Thompson R, Lindblad K, Hutton E, et al.
Cell
. 2019 May;
177(7):1781-1796.e25.
PMID: 31104845
DNA N6-adenine methylation (6mA) has recently been described in diverse eukaryotes, spanning unicellular organisms to metazoa. Here, we report a DNA 6mA methyltransferase complex in ciliates, termed MTA1c. It consists...
9.
Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, et al.
Nature
. 2019 Mar;
567(7749):535-539.
PMID: 30867594
Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription. Here we provide evidence for a class of histone post-translational modification, serotonylation of glutamine, which occurs at position...
10.
Watson E, Liu X, Thompson R, Ripoll-Rozada J, Wu M, Alwis I, et al.
ACS Cent Sci
. 2018 May;
4(4):468-476.
PMID: 29721529
The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin...