Robert E Lee Trout
Overview
Explore the profile of Robert E Lee Trout including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
269
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Recent Articles
1.
Liu B, Trout R, Chu G, McGarry D, Jackson R, Hamrick J, et al.
J Med Chem
. 2019 Nov;
63(6):2789-2801.
PMID: 31765155
A major resistance mechanism in Gram-negative bacteria is the production of β-lactamase enzymes. Originally recognized for their ability to hydrolyze penicillins, emergent β-lactamases can now confer resistance to other β-lactam...
2.
Smith A, Lin Q, Doughty V, Zhuang L, McBriar M, Kerns J, et al.
Tetrahedron
. 2010 Feb;
65(33):6470-6488.
PMID: 20161196
Evolution of a convergent synthetic strategy to access (+)-spongistatin 2 (2), a potent cytotoxic marine macrolide, is described. Highlights of the synthesis include: development of a multicomponent dithiane-mediated linchpin union...
3.
Marquis R, Lago A, Callahan J, Trout R, Gowen M, DelMar E, et al.
J Med Chem
. 2009 Jun;
52(13):3982-93.
PMID: 19492813
Functional screening of the former SmithKline Beecham compound collection against the human calcium receptor (CaR) resulted in the identification of the amino alcohol-based hit 2 (IC(50) = 11 microM). Structure-activity...
4.
Willette R, Bao W, Nerurkar S, Yue T, Doe C, Stankus G, et al.
J Pharmacol Exp Ther
. 2008 May;
326(2):443-52.
PMID: 18499744
The transient receptor potential (TRP) vanilloid subtype 4 (V4) is a nonselective cation channel that exhibits polymodal activation and is expressed in the endothelium, where it contributes to intracellular Ca2+...
5.
Marquis R, James I, Zeng J, Trout R, Thompson S, Rahman A, et al.
J Med Chem
. 2005 Oct;
48(22):6870-8.
PMID: 16250645
The extension of a previously reported cathepsin K azepanone-based inhibitor template to the design and synthesis of potent and selective inhibitors of the homologous cysteine protease cathepsin L is detailed....