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Robert A McKnight

Explore the profile of Robert A McKnight including associated specialties, affiliations and a list of published articles. Areas
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Articles 42
Citations 790
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Recent Articles
1.
Mankouski A, Miller T, Dodson R, Yu B, Yang Y, Liu J, et al.
Physiol Rep . 2022 Dec; 10(23):e15518. PMID: 36461654
Intrauterine growth restriction (IUGR) and exposure to a high-fat diet (HFD) independently increase the risk of cardiovascular disease (CVD) and hyperlipidemia. In our previous studies, IUGR increased blood pressure and...
2.
Ferguson B, Wennersten S, Demos-Davies K, Rubino M, Robinson E, Cavasin M, et al.
Am J Physiol Heart Circ Physiol . 2021 Jun; 321(2):H382-H389. PMID: 34142888
Pulmonary hypertension (PH) is associated with structural remodeling of pulmonary arteries (PAs) because of excessive proliferation of fibroblasts, endothelial cells, and smooth muscle cells (SMCs). The peptide hormone angiotensin II...
3.
Ke X, Xing B, Dahl M, Alvord J, McKnight R, Lane R, et al.
Pediatr Res . 2021 Feb; 90(5):998-1008. PMID: 33603215
Background: The brain of chronically ventilated preterm human infants is vulnerable to collateral damage during invasive mechanical ventilation (IMV). Damage is manifest, in part, by learning and memory impairments, which...
4.
Habibian J, Jefic M, Bagchi R, Lane R, McKnight R, McKinsey T, et al.
Sci Rep . 2017 Oct; 7(1):12879. PMID: 29018280
Adipose tissue inflammation is a central pathological element that regulates obesity-mediated insulin resistance and type II diabetes. Evidence demonstrates that extracellular signal-regulated kinase (ERK 1/2) activation (i.e. phosphorylation) links tumor...
5.
McKnight R, Yost C, Zinkhan E, Fu Q, Callaway C, Fung C
Physiol Genomics . 2016 Jun; 48(8):616-25. PMID: 27317589
Nutrient deprivation suppresses protein synthesis by blocking peptide elongation. Transcriptional upregulation and activation of eukaryotic elongation factor 2 kinase (eEF2K) blocks peptide elongation by phosphorylating eukaryotic elongation factor 2. Previous...
6.
McKnight R, Yost C, Yu X, Wiedmeier J, Callaway C, Brown A, et al.
Physiol Genomics . 2015 Oct; 47(12):634-43. PMID: 26487705
Intrauterine growth restriction (IUGR) is a common human pregnancy complication. IUGR offspring carry significant postnatal risk for early-onset metabolic syndrome, which is associated with persistent reduction in IGF-1 protein expression....
7.
Ke X, McKnight R, Maniar L, Sun Y, Callaway C, Majnik A, et al.
Am J Physiol Regul Integr Comp Physiol . 2015 May; 309(2):R119-27. PMID: 25972460
Intrauterine growth restriction (IUGR) increases the risk for neurodevelopment delay and neuroendocrine reprogramming in both humans and rats. Neuroendocrine reprogramming involves the glucocorticoid receptor (GR) gene that is epigenetically regulated...
8.
Fung C, Yang Y, Fu Q, Brown A, Yu B, Callaway C, et al.
Pediatr Res . 2015 Apr; 78(1):14-23. PMID: 25826117
Background: Intrauterine growth restriction (IUGR) offspring with rapid catch-up growth are at increased risk for early obesity especially in males. Persistent insulin-like growth factor-1 (IGF-1) reduction is an important risk...
9.
Fu Q, McKnight R, Callaway C, Yu X, Lane R, Majnik A
FASEB J . 2014 Dec; 29(4):1176-84. PMID: 25466885
Intrauterine growth restriction (IUGR) decreases serum IGF-1 levels. Postnatal IGF-1 expression is transcriptionally regulated by growth hormone (GH) through growth hormone response elements (GHREs). We hypothesized that IUGR disrupts the...
10.
Goodspeed D, Seferovic M, Holland W, McKnight R, Summers S, Branch D, et al.
FASEB J . 2014 Nov; 29(3):807-19. PMID: 25395450
Intrauterine growth restriction (IUGR) confers heritable alterations in DNA methylation, rendering risk of adult metabolic syndrome (MetS). Because CpG methylation is coupled to intake of essential nutrients along the one-carbon...