Rita Vanbever
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Explore the profile of Rita Vanbever including associated specialties, affiliations and a list of published articles.
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Articles
55
Citations
817
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Recent Articles
1.
Redeghieri P, Moray J, Kerff F, Gohy S, Leal T, Muyldermans S, et al.
Protein Sci
. 2024 Nov;
33(12):e5227.
PMID: 39604162
Human neutrophil elastase (hNE), a serine protease released by neutrophils during inflammation, plays a major role in the pathophysiology of several conditions especially in inflammatory lung diseases. Its inhibition constitutes,...
2.
Mahri S, Cassiers C, Gracin S, Tyteca D, Uwambayinema F, Huaux F, et al.
Int J Pharm
. 2024 Nov;
667(Pt B):124880.
PMID: 39515675
Spray drying is a widely employed method for generating dry powder formulations for inhalation. Yet, it presents substantial challenges when applied to therapeutic proteins due to stability issues. The formation...
3.
Wang Z, Vanbever R, Lorent J, Solis J, Knoop C, Van Bambeke F
J Cyst Fibros
. 2024 Feb;
23(6):1146-1152.
PMID: 38402083
Background: Biofilm-associated pulmonary infections pose therapeutic challenges in cystic fibrosis patients, especially when involving multiple bacterial species. Enzymatic degradation of the biofilm matrix may offer a potential solution to enhance...
4.
Mahri S, Wilms T, Hagedorm P, Guichard M, Vanvarenberg K, Dumoulin M, et al.
Eur J Pharm Sci
. 2023 Jul;
189:106522.
PMID: 37423579
Recombinant human deoxyribonuclease I (rhDNase, Pulmozyme®) is the most frequently used mucolytic agent for the symptomatic treatment of cystic fibrosis (CF) lung disease. Conjugation of rhDNase to polyethylene glycol (PEG)...
5.
Brancaleone P, Delefortrie Q, Descamps O, Weynand B, Vanbever R, Detry G
Am J Respir Crit Care Med
. 2022 Oct;
207(8):e71-e72.
PMID: 36315868
No abstract available.
6.
Liu X, Kouassi K, Vanbever R, Dumoulin M
Protein Sci
. 2022 Aug;
31(9):e4392.
PMID: 36040264
Conjugation to polyethylene glycol (PEG) is a widely used approach to improve the therapeutic value of proteins essentially by prolonging their body residence time. PEGylation may however induce changes in...
7.
Liu X, Vanvarenberg K, Kouassi K, Mahri S, Vanbever R
Int J Pharm
. 2021 Dec;
612:121355.
PMID: 34883205
Alpha-1 antitrypsin (AAT) is an endogenous inhibitor of serine proteases which, in physiological conditions, neutralizes the excess of neutrophil elastase and other serine proteases in tissues and especially the lungs....
8.
Reynaerts A, Vermeulen F, Mottais A, Gohy S, Lebecque P, Frederick R, et al.
J Cyst Fibros
. 2021 Sep;
21(3):407-415.
PMID: 34489187
Objectives: Two CFTR-dependent β-adrenergic sweat rate tests applying intradermal drug injections were reported to better define diagnosis and efficacy of CFTR-directed therapies. The aim of this work was to develop...
9.
Loira-Pastoriza C, Vanvarenberg K, Ucakar B, Machado Franco M, Staub A, Lemaire M, et al.
Int J Pharm
. 2021 Mar;
600:120504.
PMID: 33753161
Immunotherapy brings new hope to the fight against lung cancer. General immunostimulatory agents represent an immunotherapy strategy that has demonstrated efficacy with limited toxicity when delivered intratumorally. The goal of...
10.
Mahri S, Hardy E, Wilms T, De Keersmaecker H, Braeckmans K, De Smedt S, et al.
Int J Pharm
. 2020 Dec;
593:120107.
PMID: 33259904
Conjugation to high molecular weight (MW ≥ 20 kDa) polyethylene glycol (PEG) was previously shown to largely prolong the lung residence time of recombinant human deoxyribonuclease I (rhDNase) and improve...