Rina Plattner
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Explore the profile of Rina Plattner including associated specialties, affiliations and a list of published articles.
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22
Citations
580
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Recent Articles
11.
Sims J, Ganguly S, Bennett H, Friend J, Tepe J, Plattner R
PLoS One
. 2013 Feb;
8(1):e55509.
PMID: 23383209
Despite advances in cancer detection and prevention, a diagnosis of metastatic disease remains a death sentence due to the fact that many cancers are either resistant to chemotherapy (conventional or...
12.
Ganguly S, Plattner R
Genes Cancer
. 2012 Dec;
3(5-6):414-25.
PMID: 23226579
Although c-Abl and Arg non-receptor tyrosine kinases are well known for driving leukemia development, their role in solid tumors has not been appreciated until recently. Accumulating evidence now indicates that...
13.
Zhao H, Ou-Yang F, Chen I, Hou M, Yuan S, Chang H, et al.
Neoplasia
. 2010 Mar;
12(3):214-23.
PMID: 20234815
Targeting the estrogen receptor is an important strategy in breast cancer therapy. However, although inhibiting estrogen receptor function with specific estrogen receptor modulators can achieve a primary response in cancer...
14.
Sims J, Ganguly S, Fiore L, Holler C, Park E, Plattner R
Biochem Pharmacol
. 2009 May;
78(3):249-60.
PMID: 19427998
Previously, we demonstrated that Abl kinases are highly active in invasive breast cancer cell lines, and contribute to survival in response to nutrient deprivation, invasion and proliferation. To determine whether...
15.
Sims J, Plattner R
Cancer Chemother Pharmacol
. 2009 Apr;
64(3):629-33.
PMID: 19396599
Purpose: This study will determine whether MTT assays accurately assess the effect of STI571 (Gleevec; Abl kinase inhibitor) on the viability of cancer cells containing highly active Abl kinases. Methods:...
16.
Srinivasan D, Kaetzel D, Plattner R
Cell Signal
. 2009 Mar;
21(7):1143-50.
PMID: 19275932
Previously, we showed that Abl kinases (c-Abl, Arg) are activated downstream of PDGF in a manner dependent on Src kinases and PLC-gamma1, and promote PDGF-mediated proliferation and migration of fibroblasts....
17.
Mitra S, Beach C, Feng G, Plattner R
J Cell Sci
. 2008 Oct;
121(Pt 20):3335-46.
PMID: 18827006
Previously, we showed that Abl family tyrosine kinases are activated by growth factors, and Abl is required for transition from G1 to S phase during PDGF-mediated proliferation. Here, we show...
18.
Srinivasan D, Plattner R
Cancer Res
. 2006 Jun;
66(11):5648-55.
PMID: 16740702
The Abl family of nonreceptor tyrosine kinases consists of two related proteins, c-Abl and Abl-related gene (Arg). Activated forms of the Abl kinases (BCR-Abl, Tel-Abl, and Tel-Arg) induce the development...
19.
Plattner R, Koleske A, Kazlauskas A, Pendergast A
Mol Cell Biol
. 2004 Mar;
24(6):2573-83.
PMID: 14993293
The c-Abl nonreceptor tyrosine kinase is activated by growth factor signals such as the platelet-derived growth factor (PDGF) and functions downstream of the PDGF-beta receptor (PDGFR) to mediate biological processes...
20.
Burton E, Plattner R, Pendergast A
EMBO J
. 2003 Oct;
22(20):5471-9.
PMID: 14532119
Infection by the opportunistic bacterial pathogen Shigella flexneri stimulates tyrosine phosphorylation of host cell proteins, but the kinases involved and their effects on the regulation of cell signaling pathways during...