Rik Ossenkoppele
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Explore the profile of Rik Ossenkoppele including associated specialties, affiliations and a list of published articles.
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225
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9688
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Recent Articles
1.
Dijkstra J, Vermunt L, Venkatraghavan V, Ozhegov G, Coomans E, Ossenkoppele R, et al.
Alzheimers Res Ther
. 2025 Mar;
17(1):57.
PMID: 40051009
Background: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer's disease (AD), and drugs targeting the TREM2 protein are being...
2.
Kamps S, Hempel H, van Amerongen S, de Bruin H, van der Linden F, Venkatraghavan V, et al.
Brain Commun
. 2025 Mar;
7(2):fcaf085.
PMID: 40046332
Cavum septum pellucidum (CSP) is commonly observed upon neuroimaging examination in individuals exposed to repetitive head impacts (RHI) and post-mortem in cases with chronic traumatic encephalopathy. Consequently, CSP has been...
3.
Karlsson L, Vogel J, Arvidsson I, Astrom K, Strandberg O, Seidlitz J, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e14600.
PMID: 39985487
Introduction: Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost...
4.
de Bruin H, Groot C, Kamps S, Vijverberg E, Steward A, Dehsarvi A, et al.
Brain Commun
. 2025 Jan;
7(1):fcaf009.
PMID: 39845735
Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been...
5.
Oomens J, van Gils V, Vos S, Freeze W, Maserejian N, Curiale G, et al.
JAMA Netw Open
. 2025 Jan;
8(1):e2455571.
PMID: 39841474
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β...
6.
Wiels W, Oomens J, Engelborghs S, Baeken C, von Arnim C, Boada M, et al.
JAMA Psychiatry
. 2025 Jan;
82(3):296-310.
PMID: 39841452
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive...
7.
Vermeiren M, Calandri I, van der Flier W, van de Giessen E, Ossenkoppele R
Alzheimers Dement (Amst)
. 2024 Nov;
16(4):e70033.
PMID: 39583643
Background: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the future....
8.
Calandri I, Ardohain C, Elgani S, Seminara E, Hernandez M, Ossenkoppele R, et al.
Alzheimers Dement (Amst)
. 2024 Nov;
16(4):e12538.
PMID: 39564098
Introduction: Providing medical advice regarding lifestyle changes is currently the most effective intervention for delaying dementia onset among individuals with subjective cognitive decline (SCD). Adherence to such advice can be...
9.
Vermeiren M, Somsen J, Luurtsema G, Reesink F, Verwey N, Hempenius L, et al.
Alzheimers Res Ther
. 2024 Oct;
16(1):230.
PMID: 39427210
Background: Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer's disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in...
10.
Svenningsson A, Bocancea D, Stomrud E, van Loenhoud A, Barkhof F, Mattsson-Carlgren N, et al.
Alzheimers Res Ther
. 2024 Oct;
16(1):221.
PMID: 39396028
Background: In Alzheimer's disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological...