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Rick Vermue

Explore the profile of Rick Vermue including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 4
Citations 47
Followers 0
Related Specialties
Biochemistry
Pharmacology
Molecular Biology
Top 10 Co-Authors
Peter C de Visser
Annemieke Aartsma-Rus
Maaike van Putten
Begona Aguilera
Christa L Tanganyika-de Winter
Daan Muilwijk
Silvana M G Jirka
Tatyana G Karnaoukh
Anneke Janson
Maria L H Vlaming
Published In
Nucleic Acid Ther
Mol Ther Nucleic Acids
Affiliations
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Recent Articles
1.
Feasibility of SPECT-CT Imaging to Study the Pharmacokinetics of Antisense Oligonucleotides in a Mouse Model of Duchenne Muscular Dystrophy
van de Steeg E, Lappchen T, Aguilera B, Jansen H, Muilwijk D, Vermue R, et al.
Nucleic Acid Ther . 2017 Apr; 27(4):221-231. PMID: 28418733
Antisense oligonucleotides (AONs) are promising candidates for treatment of Duchenne muscular dystrophy (DMD), a severe and progressive disease resulting in premature death. However, more knowledge on the pharmacokinetics of new...
2.
Evaluation of 2'-Deoxy-2'-fluoro Antisense Oligonucleotides for Exon Skipping in Duchenne Muscular Dystrophy
Jirka S, Winter C, Boertje-van der Meulen J, van Putten M, Hiller M, Vermue R, et al.
Mol Ther Nucleic Acids . 2015 Dec; 4:e265. PMID: 26623937
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder typically caused by frame-shifting mutations in the DMD gene. Restoration of the reading frame would allow the production of a...
3.
Preclinical studies on intestinal administration of antisense oligonucleotides as a model for oral delivery for treatment of duchenne muscular dystrophy
van Putten M, Young C, van den Berg S, Pronk A, Hulsker M, Karnaoukh T, et al.
Mol Ther Nucleic Acids . 2014 Nov; 3:e211. PMID: 25405468
Antisense oligonucleotides (AONs) used to reframe dystrophin mRNA transcripts for Duchenne muscular dystrophy (DMD) patients are tested in clinical trials. Here, AONs are administered subcutaneously and intravenously, while the less...
4.
Peptide conjugation of 2'-O-methyl phosphorothioate antisense oligonucleotides enhances cardiac uptake and exon skipping in mdx mice
Jirka S, Heemskerk H, Winter C, Muilwijk D, Pang K, de Visser P, et al.
Nucleic Acid Ther . 2013 Dec; 24(1):25-36. PMID: 24320790
Antisense oligonucleotide (AON)-mediated exon skipping is a promising therapeutic approach for Duchenne muscular dystrophy that is currently being tested in various clinical trials. This approach is based on restoring the...