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Rick J H Wetzels

Explore the profile of Rick J H Wetzels including associated specialties, affiliations and a list of published articles. Areas
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Citations 100
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Recent Articles
1.
Heubel-Moenen F, Ansems L, Verhezen P, Wetzels R, van Oerle R, Straat R, et al.
Br J Haematol . 2022 Nov; 200(6):792-801. PMID: 36444397
The diagnostic work-up of patients referred to the haematologist for bleeding evaluation is performed in a stepwise way: bleeding history and results of screening laboratory tests guide further diagnostic evaluation....
2.
Heubel-Moenen F, Brouns S, Herfs L, Boerenkamp L, Jooss N, Wetzels R, et al.
Br J Haematol . 2022 Jan; 196(6):1388-1400. PMID: 35001370
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without evidence for von Willebrand disease or impaired platelet aggregation. The aim of...
3.
Streng A, Delnoij T, Mulder M, Sels J, Wetzels R, Verhezen P, et al.
TH Open . 2020 Nov; 4(4):e365-e375. PMID: 33235946
 Severe cases of coronavirus disease 2019 (COVID-19) can require continuous renal replacement therapy (CRRT) and/or extracorporeal membrane oxygenation (ECMO). Unfractionated heparin (UFH) to prevent circuit clotting is mandatory but monitoring...
4.
Heubel-Moenen F, Henskens Y, Verhezen P, Wetzels R, Schouten H, Beckers E
J Thromb Haemost . 2019 Apr; 17(7):1073-1084. PMID: 31033178
Background: Bleeding events in chemotherapy-induced thrombocytopenic (CIT) patients with similar platelet counts might be influenced by changes in clot lysis potential. Objectives: To investigate, in an observational study, thromboelastographic lysis...
5.
Vries M, MacRae F, Nelemans P, Kuiper G, Wetzels R, Bowman P, et al.
Thromb Res . 2018 Dec; 174:88-94. PMID: 30579151
Enhanced clot lysis is associated with bleeding, but assessment of lysis capacity remains difficult. The plasma turbidity lysis and whole blood tissue Plasminogen Activator-Rotational Thromboelastometry (tPA-ROTEM) assays estimate fibrinolysis under...
6.
Baaten C, Moenen F, Henskens Y, Swieringa F, Wetzels R, Van Oerle R, et al.
Haematologica . 2018 Jun; 103(9):1557-1567. PMID: 29880611
Severe thrombocytopenia (≤50×10 platelets/L) due to hematological malignancy and intensive chemotherapy is associated with an increased risk of clinically significant bleeding. Since the bleeding risk is not linked to the...
7.
Moenen F, Vries M, Nelemans P, van Rooy K, Vranken J, Verhezen P, et al.
Platelets . 2017 Nov; 30(1):81-87. PMID: 29135309
Light transmission aggregation (LTA) is the gold standard for the diagnosis of platelet function disorders (PFDs), but it is time-consuming and limited to specialized laboratories. Whole-blood impedance aggregometry (Multiplate) and...
8.
Kuiper G, Houben R, Wetzels R, Verhezen P, Van Oerle R, Ten Cate H, et al.
Platelets . 2017 Jan; 28(7):668-675. PMID: 28067094
Low platelet counts and hematocrit levels hinder whole blood point-of-care testing of platelet function. Thus far, no reference ranges for MEA (multiple electrode aggregometry) and PFA-100 (platelet function analyzer 100)...
9.
Olde Engberink R, Kuiper G, Wetzels R, Nelemans P, Lance M, Beckers E, et al.
J Cardiothorac Vasc Anesth . 2014 Mar; 28(2):210-6. PMID: 24630470
Objectives: In the present study, the authors have investigated whether rotational thromboelastometry (ROTEM) could predict thrombocytopenia and hypofibrinogenemia in cardiac surgery using the clot amplitude after 5 minutes (A5). Another...