Richard van Wijk
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Explore the profile of Richard van Wijk including associated specialties, affiliations and a list of published articles.
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130
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1823
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Recent Articles
1.
Traets M, Ruiter T, Levine C, Rijneveld A, Jans J, Alt C, et al.
Blood Cells Mol Dis
. 2025 Jan;
111:102909.
PMID: 39827736
Pyruvate kinase (PK), a key ATP-generating enzyme in glycolysis, is a target for novel sickle cell disease (SCD) therapies. Enhancing PK activity lowers 2,3-diphosphyglycerate (2,3-DPG), increases adenosine triphosphate (ATP), and...
2.
Vervoorn M, Ballan E, Kaffka Genaamd Dengler S, Meijborg V, de Jager S, van Wijk R, et al.
J Heart Lung Transplant
. 2024 Oct;
44(2):285-288.
PMID: 39369969
Hypothermic oxygenated perfusion (HOPE) is an emerging technique for donor heart preservation that is currently being studied in multiple clinical trials with promising results. When compared to HOPE for other...
3.
Schuchardt J, Krater M, Schlogel M, Guck J, van Oirschot-Hermans B, Bos J, et al.
Prostaglandins Leukot Essent Fatty Acids
. 2024 Aug;
202:102636.
PMID: 39159530
n3-PUFA impact health in several ways, including cardiovascular protection and anti-inflammatory effects, but the underlying mechanisms are not fully understood. In this exploratory study involving 31 healthy subjects, we aimed...
4.
Hernandez C, Peikert K, Qiao M, Darras A, de Wilde J, Bos J, et al.
Front Neurosci
. 2024 Aug;
18:1406969.
PMID: 39091345
Introduction: The unique red blood cell (RBC) properties that characterize the rare neuroacanthocytosis syndromes (NAS) have prompted the exploration of osmotic gradient ektacytometry (Osmoscan) as a diagnostic tool for these...
5.
Glenthoj A, Rasmussen A, Bendtsen S, Hasle H, Hoffmann M, Rieneck K, et al.
Orphanet J Rare Dis
. 2024 Jul;
19(1):284.
PMID: 39085840
Background: Hereditary anemias are a group of genetic diseases prevalent worldwide and pose a significant health burden on patients and societies. The clinical phenotype of hereditary anemias varies from compensated...
6.
Glenthoj A, van Beers E, van Wijk R, Rab M, Groot E, Vejlstrup N, et al.
BMJ Open
. 2024 Jul;
14(7):e083691.
PMID: 39079928
Introduction: Membranopathies encompass haemolytic disorders arising from genetic variants in erythrocyte membrane proteins, including hereditary spherocytosis and stomatocytosis. Congenital dyserythropoietic anaemia type II (CDA II) is associated with the gene...
7.
van Dijk M, Ruiter T, van der Veen S, Rab M, van Oirschot B, Bos J, et al.
Hemasphere
. 2024 Jun;
8(6):e109.
PMID: 38919958
Mitapivat is an investigational, oral, small-molecule allosteric activator of pyruvate kinase (PK). PK is a regulatory glycolytic enzyme that is key in providing the red blood cell (RBC) with sufficient...
8.
Holme S, van Wijk R, Rasmussen A, Petersen J, Glenthoj A
J Med Case Rep
. 2024 Mar;
18(1):130.
PMID: 38539245
Background: Glucose-6-phosphate isomerase deficiency is a rare genetic disorder causing hereditary nonspherocytic hemolytic anemia. It is the second most common glycolytic enzymopathy in red blood cells. About 90 cases are...
9.
The RoxyScan is a novel measurement of red blood cell deformability under oxidative and shear stress
Larkin S, Hernandez C, van Beers E, van Wijk R, Kuypers F
Sci Rep
. 2024 Mar;
14(1):6344.
PMID: 38491086
Exposure to both oxidative and shear stress, a condition that the red blood cell (RBC) continuously experiences in the circulation in vivo can be mimicked in a Couette type viscometer...
10.
Ukonmaanaho E, DellAnna S, Hakonen A, Wartiovaara-Kautto U, Kakko S, Rab M, et al.
Br J Haematol
. 2024 Feb;
204(5):2040-2048.
PMID: 38415930
The hexokinase (HK) enzyme plays a key role in red blood cell energy production. Hereditary non-spherocytic haemolytic anaemia (HNSHA) caused by HK deficiency is a rare disorder with only 12...