Richard V Benya
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Explore the profile of Richard V Benya including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Murillo G, Matusiak D, Benya R, Mehta R
J Steroid Biochem Mol Biol
. 2007 Jan;
103(3-5):763-7.
PMID: 17257827
Recently, it has been reported that 25-hydroxyvitamin D3-1alpha-hydroxylase [1alpha(OH)ase, CYP27B1], required to convert non-toxic 25-hyxdroxyvitamin D3 [25(OH)D(3)] to its active metabolite [1alpha,25(OH)(2)D(3)], is present in the epithelial cells of the...
12.
Taglia L, Matusiak D, Matkowskyj K, Benya R
Am J Physiol Gastrointest Liver Physiol
. 2006 Aug;
292(1):G182-90.
PMID: 16920698
Gastrin-releasing peptide (GRP) and its receptor (GRPR) act as morphogens when expressed in colorectal cancer (CRC), promoting the assumption of a better differentiated phenotype by regulating cell motility in the...
13.
Ruginis T, Taglia L, Matusiak D, Lee B, Benya R
J Proteome Res
. 2006 Jun;
5(6):1460-8.
PMID: 16739997
Gastrin-releasing peptide (GRP) and its receptor (GRPR) are aberrantly up-regulated in colon cancer. When expressed, they act as morphogens, retaining tumor cells in a better differentiated state and retarding metastasis....
14.
Hu Y, Benya R, Carroll R, Diamond A
J Nutr
. 2005 Dec;
135(12 Suppl):3021S-3024S.
PMID: 16317164
Selenium has been shown to reduce cancer incidence in animal models and more recent data indicate that it may be protective in humans as well. However, little is known about...
15.
Matusiak D, Murillo G, Carroll R, Mehta R, Benya R
Cancer Epidemiol Biomarkers Prev
. 2005 Oct;
14(10):2370-6.
PMID: 16214919
Considerable evidence exists to support the use of vitamin D to prevent and/or treat colorectal cancer. However, the routine use of bioactive vitamin D, 1,25-dihydroxyvitamin D3, is limited by the...
16.
Glover S, Nathaniel R, Shakir L, Perrault C, Anderson R, Tran-Son-Tay R, et al.
Am J Physiol Gastrointest Liver Physiol
. 2005 May;
288(6):G1274-82.
PMID: 15890713
Gastrin-releasing peptide (GRP) is typically viewed as a growth factor in cancer. However, we have suggested that in colon cancer, GRP acts primarily as a morphogen when it and its...
17.
Matusiak D, Glover S, Nathaniel R, Matkowskyj K, Yang J, Benya R
Am J Physiol Gastrointest Liver Physiol
. 2004 Nov;
288(4):G718-28.
PMID: 15528253
Bombesin-like peptides are uniformly thought to act as mitogens in cancer. Yet by studying human tissues, we have recently shown that bombesin and its mammalian homologue gastrin-releasing peptide act as...
18.
Matkowskyj K, Nathaniel R, Prasad R, Weihrauch D, Rao M, Benya R
Inflamm Bowel Dis
. 2004 Oct;
10(4):408-16.
PMID: 15475749
Galanin is present in enteric nerves lining the gastrointestinal (GI) tract where it is normally involved in regulating intestinal motility by binding to the galanin-1 receptor (Gal1R) subtype expressed by...
19.
Glover S, Delaney M, Dematte C, Kornberg L, Frasco M, Tran-Son-Tay R, et al.
J Cell Physiol
. 2004 Feb;
199(1):77-88.
PMID: 14978737
We have proposed that gastrin-releasing peptide (GRP) and its receptor (GRP-R) are morphogens that when aberrantly re-expressed in colon cancer promote tumor cell differentiation and retard metastasis. Because circumstantial evidence...
20.
Schumann M, Nakagawa T, Mantey S, Tokita K, Venzon D, Hocart S, et al.
J Pharmacol Exp Ther
. 2003 Sep;
307(2):597-607.
PMID: 12970386
Little is known about the function of the central portion of the second intracellular loop (i2 loop) of peptide receptors in activation of downstream pathways and receptor modulatory processes such...