Richard S Kang
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Explore the profile of Richard S Kang including associated specialties, affiliations and a list of published articles.
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12
Citations
508
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Recent Articles
1.
Liu H, Kang R, Bagnowski K, Yu J, Radecki S, Daniel W, et al.
J Invest Dermatol
. 2019 Aug;
140(2):435-444.e4.
PMID: 31421125
The activation of T helper 17 signaling plays a critical role in psoriasis pathogenesis, and systemically-administered IL-17 inhibitors are highly effective therapy for moderate-to-severe disease. We generated topically-delivered gene-regulating nanoconstructs,...
2.
Radovic-Moreno A, Chernyak N, Mader C, Nallagatla S, Kang R, Hao L, et al.
Proc Natl Acad Sci U S A
. 2015 Mar;
112(13):3892-7.
PMID: 25775582
Immunomodulatory nucleic acids have extraordinary promise for treating disease, yet clinical progress has been limited by a lack of tools to safely increase activity in patients. Immunomodulatory nucleic acids act...
3.
Pigati L, Kang R, Folsch H
Methods Cell Biol
. 2013 Dec;
118:125-37.
PMID: 24295304
Epithelial cells in culture, especially once they are polarized, are extremely hard to manipulate by transient transfection methods. The use of replication defective adenoviruses for gene expression or replication defective...
4.
Kang R, Folsch H
J Cell Biol
. 2011 Mar;
193(1):51-60.
PMID: 21444685
The autosomal recessive hypercholesterolemia protein (ARH) is well known for its role in clathrin-mediated endocytosis of low-density lipoprotein receptors (LDLRs). During uptake, ARH directly binds to the FxNPxY signal in...
5.
Kang R, Folsch H
F1000 Biol Rep
. 2010 Feb;
1:83.
PMID: 20161436
The role of the exocyst complex has been studied mainly in the context of basolateral sorting of cargos in polarized cells. Recent developments indicate an extended yet specific function of...
6.
Fields I, King S, Shteyn E, Kang R, Folsch H
Mol Biol Cell
. 2009 Oct;
21(1):95-105.
PMID: 19864464
Polarized epithelial cells coexpress two almost identical AP-1 clathrin adaptor complexes: the ubiquitously expressed AP-1A and the epithelial cell-specific AP-1B. The only difference between the two complexes is the incorporation...
7.
Sahu S, Swanson K, Kang R, Huang K, Brubaker K, Ratcliff K, et al.
J Mol Biol
. 2007 Dec;
375(5):1444-56.
PMID: 18089292
The recruitment of chromatin-modifying coregulator complexes by transcription factors to specific sites of the genome constitutes an important step in many eukaryotic transcriptional regulatory pathways. The histone deacetylase-associated Sin3 corepressor...
8.
Fields I, Shteyn E, Pypaert M, Proux-Gillardeaux V, Kang R, Galli T, et al.
J Cell Biol
. 2007 May;
177(3):477-88.
PMID: 17485489
The epithelial cell-specific adaptor complex AP-1B is crucial for correct delivery of many transmembrane proteins from recycling endosomes to the basolateral plasma membrane. Subsequently, membrane fusion is dependent on the...
9.
Swanson K, Knoepfler P, Huang K, Kang R, Cowley S, Laherty C, et al.
Nat Struct Mol Biol
. 2004 Jul;
11(8):738-46.
PMID: 15235594
Recruitment of the histone deacetylase (HDAC)-associated Sin3 corepressor is an obligatory step in many eukaryotic gene silencing pathways. Here we show that HBP1, a cell cycle inhibitor and regulator of...
10.
Cowley S, Kang R, Frangioni J, Yada J, Degrand A, Radhakrishnan I, et al.
Mol Cell Biol
. 2004 Mar;
24(7):2698-709.
PMID: 15024060
The recruitment of corepressors by DNA-bound repressors is likely to be a critical rate-limiting step in the transcriptional regulation of many genes. An excellent paradigm for such an interaction is...