Richard Obexer
Overview
Explore the profile of Richard Obexer including associated specialties, affiliations and a list of published articles.
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14
Citations
327
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Recent Articles
1.
Hilditch A, Romanyuk A, Hodgson L, Mantell J, Neal C, Verkade P, et al.
J Am Chem Soc
. 2024 Apr;
146(15):10240-10245.
PMID: 38578222
Cellular compartments formed by biomolecular condensation are widespread features of cell biology. These organelle-like assemblies compartmentalize macromolecules dynamically within the crowded intracellular environment. However, the intermolecular interactions that produce condensed...
2.
Radley E, Davidson J, Foster J, Obexer R, Bell E, Green A
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
135(52):e202309305.
PMID: 38516574
The development and implementation of sustainable catalytic technologies is key to delivering our net-zero targets. Here we review how engineered enzymes, with a focus on those developed using directed evolution,...
3.
Hutton A, Foster J, Crawshaw R, Hardy F, Johannissen L, Lister T, et al.
Nat Commun
. 2024 Mar;
15(1):1956.
PMID: 38438341
Directed evolution of computationally designed enzymes has provided new insights into the emergence of sophisticated catalytic sites in proteins. In this regard, we have recently shown that a histidine nucleophile...
4.
Hilditch A, Romanyuk A, Cross S, Obexer R, McManus J, Woolfson D
Nat Chem
. 2023 Sep;
16(1):89-97.
PMID: 37710047
Recent advances in de novo protein design have delivered a diversity of discrete de novo protein structures and complexes. A new challenge for the field is to use these designs...
5.
Radley E, Davidson J, Foster J, Obexer R, Bell E, Green A
Angew Chem Int Ed Engl
. 2023 Aug;
62(52):e202309305.
PMID: 37651344
The development and implementation of sustainable catalytic technologies is key to delivering our net-zero targets. Here we review how engineered enzymes, with a focus on those developed using directed evolution,...
6.
Trimble J, Crawshaw R, Hardy F, Levy C, Brown M, Fuerst D, et al.
Nature
. 2022 Sep;
611(7937):709-714.
PMID: 36130727
The ability to program new modes of catalysis into proteins would allow the development of enzyme families with functions beyond those found in nature. To this end, genetic code expansion...
7.
Stefan E, Obexer R, Hofmann S, Vu Huu K, Huang Y, Morgner N, et al.
Elife
. 2021 Apr;
10.
PMID: 33929325
ATP-binding cassette (ABC) transporters constitute the largest family of primary active transporters involved in a multitude of physiological processes and human diseases. Despite considerable efforts, it remains unclear how ABC...
8.
Nagano M, Huang Y, Obexer R, Suga H
J Am Chem Soc
. 2021 Mar;
143(12):4741-4750.
PMID: 33733757
Here, we report a method for the one-pot ribosomal synthesis of macrocyclic depsipeptides. This method is based on a Ser-Pro-Cys-Gly (SPCG) motif discovered by selection of peptides for the function...
9.
Obexer R, Pott M, Zeymer C, Griffiths A, Hilvert D
Protein Eng Des Sel
. 2017 Sep;
30(7):531.
PMID: 28873983
No abstract available.
10.
Walport L, Obexer R, Suga H
Curr Opin Biotechnol
. 2017 Aug;
48:242-250.
PMID: 28783603
The ready availability of potent peptide binders for any desired target highlights their potential impact as therapeutic agents. Despite their versatility, however, peptides tend to display unfavourable pharmacological properties, such...