Richard N Freiman
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Explore the profile of Richard N Freiman including associated specialties, affiliations and a list of published articles.
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27
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642
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Recent Articles
1.
Abt K, Bartholomew M, Nixon A, Richman H, Gura M, Seymour K, et al.
bioRxiv
. 2025 Jan;
PMID: 39829852
Female reproductive senescence results from the regulated depletion of a finite pool of oocytes called the ovarian reserve. This pool of oocytes is initially established during fetal development, but the...
2.
Gura M, Bartholomew M, Abt K, Relovska S, Seymour K, Freiman R
Front Cell Dev Biol
. 2023 Oct;
11:1270408.
PMID: 37900284
Prospermatogonia (ProSpg) link the embryonic development of male primordial germ cells to the healthy establishment of postnatal spermatogonia and spermatogonial stem cells. While these spermatogenic precursor cells undergo the characteristic...
3.
James N, Gura M, Woodman M, Freiman R, Ribeiro J
Med Oncol
. 2022 May;
39(5):71.
PMID: 35568777
Human epididymis protein-4 (HE4/WFDC2) has been well-studied as an ovarian cancer clinical biomarker. To improve our understanding of its functional role in high grade serous ovarian cancer, we determined transcriptomic...
4.
Gura M, Relovska S, Abt K, Seymour K, Wu T, Kaya H, et al.
Development
. 2022 Jan;
149(3).
PMID: 35043944
Establishment of a healthy ovarian reserve is contingent upon numerous regulatory pathways during embryogenesis. Previously, mice lacking TBP-associated factor 4b (Taf4b) were shown to exhibit a diminished ovarian reserve. However,...
5.
Sloutskin A, Shir-Shapira H, Freiman R, Juven-Gershon T
Front Cell Dev Biol
. 2021 Sep;
9:666508.
PMID: 34568311
The development of multicellular organisms and the uniqueness of each cell are achieved by distinct transcriptional programs. Multiple processes that regulate gene expression converge at the core promoter region, an...
6.
Gustafson E, Seymour K, Sigrist K, Rooij D, Freiman R
Mol Cell Biol
. 2020 Jan;
40(7).
PMID: 31932482
TAF4b is a subunit of the TFIID complex that is highly expressed in the ovary and testis and required for mouse fertility. TAF4b-deficient male mice undergo a complex series of...
7.
Gura M, Mikedis M, Seymour K, de Rooij D, Page D, Freiman R
PLoS Genet
. 2020 Jan;
16(1):e1008515.
PMID: 31914128
Germ cells undergo many developmental transitions before ultimately becoming either eggs or sperm, and during embryonic development these transitions include epigenetic reprogramming, quiescence, and meiosis. To begin understanding the transcriptional...
8.
James N, Beffa L, Oliver M, Borgstadt A, Emerson J, Chichester C, et al.
Oncotarget
. 2019 Jun;
10(36):3315-3327.
PMID: 31164954
Dual specificity phosphatase 6 (DUSP6) is a protein phosphatase that deactivates extracellular-signal-regulated kinase (ERK). Since the ovarian cancer biomarker human epididymis protein 4 (HE4) interacts with the ERK pathway, we...
9.
Spade D, Dere E, Hall S, Schorl C, Freiman R, Boekelheide K
Toxicol Sci
. 2018 Oct;
167(2):546-558.
PMID: 30329139
Exposure to excess retinoic acid (RA) disrupts the development of the mammalian testicular seminiferous cord. However, the molecular events surrounding RA-driven loss of cord structure have not previously been examined....
10.
Grive K, Gustafson E, Seymour K, Baddoo M, Schorl C, Golnoski K, et al.
PLoS Genet
. 2016 Jun;
12(6):e1006128.
PMID: 27341508
TAF4b is a gonadal-enriched subunit of the general transcription factor TFIID that is implicated in promoting healthy ovarian aging and female fertility in mice and humans. To further explore the...