Richard Longnecker
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Explore the profile of Richard Longnecker including associated specialties, affiliations and a list of published articles.
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147
Citations
4072
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Recent Articles
11.
Hayes C, Villota C, McEnany F, Ceron S, Awasthi S, Szpara M, et al.
J Infect Dis
. 2022 Apr;
226(9):1499-1509.
PMID: 35451492
Herpes simplex virus (HSV) infection of the neonatal brain causes severe encephalitis and permanent neurologic deficits. However, infants infected with HSV at the time of birth follow varied clinical courses,...
12.
Hayes C, Giraldo D, Wilcox D, Longnecker R
J Virol
. 2021 Dec;
96(4):e0178321.
PMID: 34878914
No abstract available.
13.
Fan Q, Longnecker R, Connolly S
J Virol
. 2021 Aug;
95(22):e0105021.
PMID: 34431697
The viral fusion protein glycoprotein B (gB) is conserved in all herpesviruses and is essential for virus entry. During entry, gB fuses viral and host cell membranes by refolding from...
14.
Hayes C, Wilcox D, Yang Y, Coleman G, Brown M, Longnecker R
PLoS Pathog
. 2021 Feb;
17(2):e1009285.
PMID: 33524073
Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic viral encephalitis, and despite targeted antiviral therapy, outcomes remain poor. Although the innate immune system is critical for...
15.
Connolly S, Jardetzky T, Longnecker R
Nat Rev Microbiol
. 2020 Oct;
19(2):110-121.
PMID: 33087881
Herpesviruses are ubiquitous, double-stranded DNA, enveloped viruses that establish lifelong infections and cause a range of diseases. Entry into host cells requires binding of the virus to specific receptors, followed...
16.
Fish K, Comoglio F, Shaffer 3rd A, Ji Y, Pan K, Scheich S, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(42):26318-26327.
PMID: 33020271
Epstein-Barr virus (EBV) infects human B cells and reprograms them to allow virus replication and persistence. One key viral factor in this process is latent membrane protein 2A (LMP2A), which...
17.
Chen J, Schaller S, Jardetzky T, Longnecker R
J Virol
. 2020 Aug;
94(21).
PMID: 32847853
Both Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are human gammaherpesviruses and are important in a variety of malignancies. Eph family receptor tyrosine kinase A2 (EphA2) is a cellular...
18.
Giraldo D, Wilcox D, Longnecker R
mBio
. 2020 May;
11(3).
PMID: 32457247
Newborns are particularly susceptible to severe forms of herpes simplex virus 1 (HSV-1) infection, including encephalitis and multisystemic disseminated disease. The underlying age-dependent differences in the immune response that explain...
19.
Park S, Riccio R, Kopp S, Ifergan I, Miller S, Longnecker R
mBio
. 2020 May;
11(3.
PMID: 32398314
Ocular herpes simplex virus 1 (HSV-1) infection leads to an immunopathogenic disease called herpes stromal keratitis (HSK), in which CD4 T cell-driven inflammation contributes to irreversible damage to the cornea....
20.
Chen J, Longnecker R
FEMS Microbiol Rev
. 2019 Oct;
43(6):674-683.
PMID: 31584659
Epstein-Barr Virus (EBV) is etiologically associated with multiple human malignancies including Burkitt lymphoma and Hodgkin disease as well as nasopharyngeal and gastric carcinoma. Entry of EBV into target cells is...