Richard J Lessells
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Explore the profile of Richard J Lessells including associated specialties, affiliations and a list of published articles.
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78
Citations
5194
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Recent Articles
1.
Choga W, Gustani-Buss E, Tegally H, Maruapula D, Yu X, Moir M, et al.
Virus Evol
. 2024 Dec;
10(1):veae095.
PMID: 39720788
Botswana, like the rest of the world, has been significantly impacted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In December 2022, we detected a monophyletic cluster of genomes comprising...
2.
Sigal A, Neher R, Lessells R
Nat Rev Microbiol
. 2024 Nov;
PMID: 39587352
SARS-CoV-2 causes an acute respiratory tract infection that resolves in most people in less than a month. Yet some people with severely weakened immune systems fail to clear the virus,...
3.
Kassanjee R, Davies M, Heekes A, Mahomed H, Hawkridge A, Morden E, et al.
Vaccines (Basel)
. 2024 Jun;
12(6).
PMID: 38932357
There are few data on the real-world effectiveness of COVID-19 vaccines and boosting in Africa, which experienced widespread SARS-CoV-2 infection before vaccine availability. We assessed the association between vaccination and...
4.
Skrivankova V, Huwa J, Muula G, Chiwaya G, Banda E, Buleya S, et al.
Clin Infect Dis
. 2024 Jun;
80(1):120-128.
PMID: 38847281
Background: People with human immunodeficiency virus (PWH) on first-line, nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy (ART) were routinely switched to tenofovir-lamivudine-dolutegravir. We examined virologic outcomes and drug resistance in ART programs...
5.
Karim F, Riou C, Bernstein M, Jule Z, Lustig G, van Graan S, et al.
Nat Commun
. 2024 Mar;
15(1):2360.
PMID: 38491050
SARS-CoV-2 clearance requires adaptive immunity but the contribution of neutralizing antibodies and T cells in different immune states is unclear. Here we ask which adaptive immune responses associate with clearance...
6.
Kassanjee R, Davies M, Heekes A, Mahomed H, Hawkridge A, Wolmarans M, et al.
medRxiv
. 2024 Feb;
PMID: 38343866
Background: There are few data on the real-world effectiveness of COVID-19 vaccines and boosting in Africa, which experienced high levels of SARS-CoV-2 infection in a mostly vaccine-naïve population, and has...
7.
Tshiabuila D, Choga W, James S, Maponga T, Preiser W, van Zyl G, et al.
medRxiv
. 2024 Jan;
PMID: 38293032
Chronic hepatitis B virus (HBV) infection remains a significant public health concern, particularly in Africa, where there is a substantial burden. HBV is an enveloped virus, with isolates being classified...
8.
Gandhi R, Castle A, de Oliveira T, Lessells R
N Engl J Med
. 2023 Dec;
389(26):2468-2476.
PMID: 38157503
No abstract available.
9.
Asare K, Sookrajh Y, van der Molen J, Khubone T, Lewis L, Lessells R, et al.
Lancet Glob Health
. 2023 Dec;
12(2):e282-e291.
PMID: 38142692
Background: Dolutegravir (DTG) is recommended for second-line antiretroviral therapy (ART) after virological failure on first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens in people living with HIV in low-income and middle-income...
10.
Khan K, Lustig G, Romer C, Reedoy K, Jule Z, Karim F, et al.
Nat Commun
. 2023 Dec;
14(1):8078.
PMID: 38057313
Omicron BA.2.86 subvariant differs from Omicron BA.2 as well as recently circulating variants by over 30 mutations in the spike protein alone. Here we report on the isolation of the...