Richard J Elsworthy
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Explore the profile of Richard J Elsworthy including associated specialties, affiliations and a list of published articles.
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10
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92
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Recent Articles
1.
OAS1: A Protective Mechanism for Alzheimer's Disease? An Exploration of Data and Possible Mechanisms
Elsworthy R, Pearce A, Masoudzadeh F, Koska K, Lodhiya H, Meher G, et al.
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859237
The immune system and neuroinflammation are now well established in the aetiology of neurodegeneration. Previous studies of transcriptomic and gene association studies have highlighted the potential of the 2'-5' oligoadenylate...
2.
Spencer F, Elsworthy R, Breen L, Bishop J, Dunleavy C, Aldred S
Trials
. 2025 Jan;
26(1):20.
PMID: 39828710
Background: Alzheimer's disease is caused by modifiable and non-modifiable risk factors. Randomised controlled trials have investigated whether the strongest genetic risk factor for Alzheimer's disease, APOE4, impacts the effectiveness of...
3.
Elsworthy R, Finelli M, Aqattan S, Dunleavy C, King M, Ludlam A, et al.
J Neurochem
. 2024 Dec;
169(1):e16267.
PMID: 39696767
Altered energy metabolism in Alzheimer's disease (AD) is a major pathological hallmark implicated in the early stages of the disease process. Astrocytes play a central role in brain homeostasis and...
4.
Spencer F, Elsworthy R, Breen L, Bishop J, Morrissey S, Aldred S
J Alzheimers Dis
. 2024 Sep;
101(4):1029-1042.
PMID: 39269836
Background: Modifiable (physical activity) and non-modifiable (sex and genotype) risk factors interact to affect Alzheimer's disease (AD) risk. Further investigation is necessary to understand if these factors influence brain volume...
5.
Dunleavy C, Elsworthy R, Wood S, Allott K, Spencer F, Upthegrove R, et al.
Brain Behav Immun
. 2024 Jun;
120:379-390.
PMID: 38906488
Introduction: First-Episode Psychosis (FEP) is a devastating mental health condition that commonly emerges during early adulthood, and is characterised by a disconnect in perceptions of reality. Current evidence suggests that...
6.
Elsworthy R, Jong S, Hanson S, Shannon O, Jennings A, Gillings R, et al.
Front Public Health
. 2024 May;
12:1371453.
PMID: 38784572
Introduction: Physical inactivity and sedentary behaviour are linked to increased risk of cardiovascular disease, infections and dementia, as well as placing a significant economic burden on healthcare systems. The implementation...
7.
Elsworthy R, Hill E, Dunleavy C, Aldred S
Front Aging Neurosci
. 2022 Dec;
14:1056507.
PMID: 36533182
Much of the early research into AD relies on a neuron-centric view of the brain, however, evidence of multiple altered cellular interactions between glial cells and the vasculature early in...
8.
Dunleavy C, Elsworthy R, Upthegrove R, Wood S, Aldred S
Acta Psychiatr Scand
. 2022 Feb;
146(1):6-20.
PMID: 35202480
Objective: To provide a comprehensive analysis of cytokine perturbations in antipsychotic-naïve first-episode psychosis (FEP) populations and assess the relationship between inflammatory biomarkers and negative symptom severity. Methods: A systematic review...
9.
Elsworthy R, King M, Grainger A, Fisher E, Crowe J, Alqattan S, et al.
Mol Cell Neurosci
. 2021 May;
114:103631.
PMID: 34022327
Introduction: Presenilin-1 (PSEN1) gene mutations are the most common cause of familial Alzheimer's disease (fAD) and are known to interfere with activity of the membrane imbedded γ-secretase complex. PSEN1 mutations...
10.
Fisher E, Wood S, Elsworthy R, Upthegrove R, Aldred S
Transl Psychiatry
. 2020 Jul;
10(1):254.
PMID: 32709912
First-episode psychosis (FEP) is a psychiatric disorder, characterised by positive and negative symptoms, usually emerging during adolescence and early adulthood. FEP represents an early intervention opportunity for intervention in psychosis....