Richard F Luduena
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Explore the profile of Richard F Luduena including associated specialties, affiliations and a list of published articles.
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35
Citations
571
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Recent Articles
1.
Luduena R, Walss-Bass C, Portyanko A, Guo J, Yeh I
Front Cell Dev Biol
. 2022 Jun;
10:870088.
PMID: 35706904
Microtubules are organelles that usually occur only in the cytosol. Walss et al. (1999) discovered the βII isotype of tubulin, complexed with , in the nuclei of certain cultured cells,...
2.
Luduena R
Front Mol Neurosci
. 2022 May;
15:838393.
PMID: 35493322
Microtubules, are formed of the protein tubulin, which is a heterodimer of α- and β-tubulin subunits. Both α- and β-tubulin exist as numerous isotypes, differing in amino acid sequence and...
3.
Guo J, Kim H, Asmis R, Luduena R
Cytoskeleton (Hoboken)
. 2018 Apr;
75(7):283-289.
PMID: 29663696
Microtubules are a major component of the neuronal cytoskeleton. Tubulin, the subunit protein of microtubules, is an α/β heterodimer. Both α and β exist as families of isotypes, whose members...
4.
Wang W, Zhang H, Wang X, Patterson J, Winter P, Graham K, et al.
Protoplasma
. 2016 Dec;
254(3):1163-1173.
PMID: 27943021
Tubulin is the target for very widely used anti-tumor drugs, including Vinca alkaloids, taxanes, and epothilones, which are an important component of chemotherapy in breast cancer and other malignancies. Paclitaxel...
5.
Yeh L, Banerjee A, Prasad V, Tuszynski J, Weis A, Bakos T, et al.
Invest New Drugs
. 2015 Dec;
34(1):129-37.
PMID: 26686345
The subunit protein of microtubules is tubulin, which has been the target for some of the most successful and widely used anti-tumor drugs. Most of the drugs that target tubulin...
6.
St George M, Ayoub A, Banerjee A, Churchill C, Winter P, Klobukowski M, et al.
PLoS One
. 2015 Jun;
10(6):e0129168.
PMID: 26052950
Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this...
7.
Luduena R
Int Rev Cell Mol Biol
. 2013 Jan;
302:41-185.
PMID: 23351710
Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent...
8.
Holm A, Grande P, Luduena R, Olde B, Prasad V, Leeb-Lundberg L, et al.
Mol Cell Biochem
. 2012 Mar;
366(1-2):239-49.
PMID: 22451019
The G protein-coupled oestrogen receptor GPER1, also known as GPR30, has been implicated in oestrogen signalling, but the physiological importance of GPER1 is not fully understood. The GPER1 agonist G-1...
9.
Moehle M, Luduena R, Haroutunian V, Meador-Woodruff J, McCullumsmith R
Schizophr Res
. 2012 Jan;
135(1-3):181-6.
PMID: 22264600
A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, β-tubulin, were recently demonstrated...
10.
Guo J, Qiang M, Luduena R
Brain Res
. 2011 Oct;
1420:8-18.
PMID: 21962533
Tubulin, the subunit protein of microtubules, is an α/β heterodimer. Both α- and β-tubulin exist as numerous isotypes, differing in their amino acid sequences and encoded by different genes. The...