Richard D Dix
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Explore the profile of Richard D Dix including associated specialties, affiliations and a list of published articles.
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25
Citations
301
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Recent Articles
1.
Liu Z, Garcia Reino E, Harschnitz O, Guo H, Chan Y, Khobrekar N, et al.
Sci Immunol
. 2023 Apr;
8(82):eade2860.
PMID: 37083451
Inborn errors of TLR3-dependent type I IFN immunity in cortical neurons underlie forebrain herpes simplex virus-1 (HSV-1) encephalitis (HSE) due to uncontrolled viral growth and subsequent cell death. We report...
2.
Guo H, Koehler H, Mocarski E, Dix R
PLoS Pathog
. 2022 Sep;
18(9):e1010857.
PMID: 36121858
Invasion of the brain by herpes simplex virus 1 (HSV1) can lead to the development of herpes simplex encephalitis (HSE) that is often associated with significant morbidity and mortality regardless...
3.
Guo H, Koehler H, Dix R, Mocarski E
Front Microbiol
. 2022 Apr;
13:869064.
PMID: 35464953
Herpes simplex virus type 1 (HSV1) remains one of the most ubiquitous human pathogens on earth. The classical presentation of HSV1 infection occurs as a recurrent lesions of the oral...
4.
Oh J, Carter J, Dix R
Pathogens
. 2021 Aug;
10(7).
PMID: 34358000
With the appearance of the worldwide AIDS pandemic four decades ago came a number of debilitating opportunistic infections in patients immunosuppressed by the pathogenic human retrovirus HIV. Among these was...
5.
Carter J, Nemeno J, Oh J, Houghton J, Dix R
Exp Eye Res
. 2021 Jun;
209:108651.
PMID: 34097907
Pyroptosis is a caspase-dependent programmed cell death pathway that initiates and sustains inflammation through release of pro-inflammatory cytokines interleukin (IL)-1β and IL-18 following formation of gasdermin D (GSDMD)-mediated membrane pores....
6.
Mora Scarpetta G, Carter J, Nemeno J, Dix R
Cytokine
. 2021 Jun;
144:155596.
PMID: 34078571
Interleukin-1α (IL-1α) is an alarmin involved in the recruitment of macrophages and neutrophils during tissue inflammation. IL-1α can undergo cleavage by proteases, such as calpain-1, that enhances IL-1α binding to...
7.
Carter J, Gardner J, Poling B, Welch M, Nemeno J, Houghton J, et al.
PLoS Pathog
. 2020 Nov;
16(11):e1009032.
PMID: 33156834
Human cytomegalovirus (HCMV) is an opportunistic human herpesvirus that causes a sight-threatening retinitis in immunosuppressed patients, especially those with AIDS. Using an established model of experimental murine cytomegalovirus (MCMV) retinitis...
8.
Oh J, Carter J, Nemeno J, Dix R
J Med Virol
. 2019 Nov;
92(3):394-398.
PMID: 31670405
The mechanisms that contribute to retinal tissue destruction during the onset and progression of AIDS-related human cytomegalovirus (HCMV) retinitis remain unclear. Evidence for the stimulation of multiple cell death pathways...
9.
Alston C, Dix R
Front Immunol
. 2019 Apr;
10:732.
PMID: 31031749
Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are...
10.
Chien H, Alston C, Dix R
J Virol
. 2018 Jul;
92(18).
PMID: 29976680
AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine...