Richard B Thorpe
Overview
Explore the profile of Richard B Thorpe including associated specialties, affiliations and a list of published articles.
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6
Citations
68
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Recent Articles
1.
Blum-Johnston C, Thorpe R, Wee C, Opsahl R, Romero M, Murray S, et al.
Am J Physiol Regul Integr Comp Physiol
. 2018 Mar;
314(6):R870-R882.
PMID: 29513562
Bradykinin-induced activation of the pulmonary endothelium triggers a rise in intracellular Ca that activates nitric oxide (NO)-dependent vasorelaxation. Chronic hypoxia is commonly associated with increased pulmonary vascular tone, which can...
2.
Silpanisong J, Kim D, Williams J, Adeoye O, Thorpe R, Pearce W
Am J Physiol Cell Physiol
. 2017 Jun;
313(2):C207-C218.
PMID: 28566491
In utero hypoxia influences the structure and function of most fetal arteries, including those of the developing cerebral circulation. Whereas the signals that initiate this hypoxic remodeling remain uncertain, these...
3.
Thorpe R, Hubbell M, Silpanisong J, Williams J, Pearce W
Am J Physiol Heart Circ Physiol
. 2017 May;
313(1):H207-H219.
PMID: 28550175
Long-term hypoxia (LTH) attenuates nitric oxide-induced vasorelaxation in ovine middle cerebral arteries. Because cGMP-dependent protein kinase (PKG) is an important mediator of NO signaling in vascular smooth muscle, we tested...
4.
Blum-Johnston C, Thorpe R, Wee C, Romero M, Brunelle A, Blood Q, et al.
Am J Physiol Lung Cell Mol Physiol
. 2015 Dec;
310(3):L271-86.
PMID: 26637638
Bradykinin-induced activation of the pulmonary endothelium triggers nitric oxide production and other signals that cause vasorelaxation, including stimulation of large-conductance Ca(2+)-activated K(+) (BKCa) channels in myocytes that hyperpolarize the plasma...
5.
Thorpe R, Stockman S, Williams J, Lincoln T, Pearce W
Am J Physiol Regul Integr Comp Physiol
. 2013 Mar;
304(9):R734-43.
PMID: 23447135
Chronic hypoxia attenuates soluble guanylate cyclase-induced vasorelaxation in serotonin (5-HT)-contracted ovine carotid arteries. Because protein kinase G (PKG) mediates many effects of soluble guanylate cyclase activation through phosphorylation of multiple...
6.
Hubbell M, Semotiuk A, Thorpe R, Adeoye O, Butler S, Williams J, et al.
Am J Physiol Cell Physiol
. 2012 Sep;
303(10):C1090-103.
PMID: 22992677
Chronic hypoxia increases vascular endothelial growth factor (VEGF) and thereby promotes angiogenesis. The present study explores the hypothesis that hypoxic increases in VEGF also remodel artery wall structure and contractility...