Richard A Sidner
Overview
Explore the profile of Richard A Sidner including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
673
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Recent Articles
1.
Martens G, Ladowski J, Estrada J, Wang Z, Reyes L, Easlick J, et al.
Transplantation
. 2019 Apr;
103(8):1620-1629.
PMID: 30951017
Background: Highly sensitized patients are difficult to match with suitable renal allograft donors and may benefit from xenotransplant trials. We evaluate antibody binding from sensitized patients to pig cells and...
2.
Martens G, Reyes L, Li P, Butler J, Ladowski J, Estrada J, et al.
Transplantation
. 2017 Jan;
101(4):e86-e92.
PMID: 28114170
Background: Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte...
3.
Wang Z, Martens G, Blankenship R, Sidner R, Li P, Estrada J, et al.
Transplantation
. 2016 Jul;
101(3):517-523.
PMID: 27379553
Background: The rapidly improving tools of genetic engineering may make it possible to overcome the humoral immune barrier that prevents xenotransplantation. We hypothesize that levels of human antibody binding to...
4.
Butler J, Paris L, Blankenship R, Sidner R, Martens G, Ladowski J, et al.
Transplantation
. 2016 Feb;
100(3):571-6.
PMID: 26906939
Background: A profound thrombocytopenia limits hepatic xenotransplantation in the pig-to-primate model. Porcine livers also have shown the ability to phagocytose human platelets in the absence of immune-mediated injury. Recently, inactivation...
5.
Paris L, Estrada J, Li P, Blankenship R, Sidner R, Reyes L, et al.
Xenotransplantation
. 2015 Mar;
22(3):203-10.
PMID: 25728617
Background: The lethal thrombocytopenia that accompanies liver xenotransplantation is a barrier to clinical application. Human platelets are bound by the asialoglycoprotein receptor (ASGR) on pig sinusoidal endothelial cells and phagocytosed....
6.
Reyes L, Estrada J, Wang Z, Blosser R, Smith R, Sidner R, et al.
J Immunol
. 2014 Oct;
193(11):5751-7.
PMID: 25339675
Pigs are emerging as important large animal models for biomedical research, and they may represent a source of organs for xenotransplantation. The MHC is pivotal to the function of the...
7.
Reyes L, Estrada J, Ivary B, Sidner R, Paris L, Tector A
J Surg Res
. 2013 Jul;
184(2):e37-42.
PMID: 23890396
Background: The process of selecting transgenic cells has been one of the bottlenecks in the generation of transgenic animals by somatic cell nuclear transfer (SCNT). In particular, selection for the...
8.
Chihara R, Lutz A, Paris L, Wang Z, Sidner R, Heyrman A, et al.
J Surg Res
. 2013 May;
184(2):1123-33.
PMID: 23673165
Background: Antibody-mediated rejection continues to be an obstacle for xenotransplantation despite development of α1,3-galactosyltransferase knockout (GTKO) pigs. Fibronectin (Fn) from GTKO pigs was identified as a xenoantigen in baboons. N-glycolylneuraminic...
9.
Lutz A, Li P, Estrada J, Sidner R, Chihara R, Downey S, et al.
Xenotransplantation
. 2013 Feb;
20(1):27-35.
PMID: 23384142
Background: Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens. Methods:...
10.
Paris L, Chihara R, Sidner R, Tector A, Burlak C
Xenotransplantation
. 2012 Feb;
19(1):31-9.
PMID: 22360751
Background: Acute thrombocytopenia was revealed as a limiting factor to porcine liver xenotransplantation from in vitro and in vivo studies using porcine liver in human and baboon transplant models. The...