Rhian Bonnici
Overview
Explore the profile of Rhian Bonnici including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
115
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0
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Recent Articles
1.
Messina N, Germano S, Chung A, van de Sandt C, Stevens N, Allen L, et al.
Clin Transl Immunology
. 2025 Jan;
14(1):e70023.
PMID: 39872402
Objectives: Bacille Calmette-Guérin (BCG) vaccination has off-target effects on disease risk for unrelated infections and immune responses to vaccines. This study aimed to determine the immunomodulatory effects of BCG vaccination...
2.
Morgan B, Lyons E, Handley A, Bogdanovic-Sakran N, Pavlic D, Witte D, et al.
Viruses
. 2024 Sep;
16(9).
PMID: 39339964
High titres of rotavirus-specific maternal antibodies may contribute to lower rotavirus vaccine efficacy in low- and middle-income countries (LMICs). RV3-BB vaccine (G3P[6]) is based on a neonatal rotavirus strain that...
3.
Messina N, Germano S, McElroy R, Bonnici R, Grubor-Bauk B, Lynn D, et al.
EBioMedicine
. 2024 Apr;
103:105100.
PMID: 38663355
Background: The COVID-19 pandemic led to the rapid development and deployment of several highly effective vaccines against SARS-CoV-2. Recent studies suggest that these vaccines may also have off-target effects on...
4.
Pittet L, Messina N, Orsini F, Moore C, Abruzzo V, Barry S, et al.
N Engl J Med
. 2023 Apr;
388(17):1582-1596.
PMID: 37099341
Background: The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19). Methods: In this international, double-blind, placebo-controlled trial, we randomly...
5.
Messina N, Germano S, McElroy R, Rudraraju R, Bonnici R, Pittet L, et al.
Clin Transl Immunology
. 2022 May;
11(4):e1387.
PMID: 35573165
Background And Objectives: Because of its beneficial off-target effects against non-mycobacterial infectious diseases, bacillus Calmette-Guérin (BCG) vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple...
6.
Pittet L, Cox L, Freyne B, Germano S, Bonnici R, Gardiner K, et al.
Vaccine
. 2022 Feb;
40(9):1334-1341.
PMID: 35105495
Introduction: Bacille Calmette-Guérin (BCG) and hepatitis B (HBV) vaccines are frequently given concomitantly at birth. Neonatal BCG vaccination induces off-target immunological effects. Whether HBV vaccine has immunomodulatory effects is unknown....
7.
Witte D, Handley A, Jere K, Bogandovic-Sakran N, Mpakiza A, Turner A, et al.
Lancet Infect Dis
. 2022 Jan;
22(5):668-678.
PMID: 35065683
Background: Rotavirus vaccines reduce rotavirus-related deaths and hospitalisations but are less effective in high child mortality countries. The human RV3-BB neonatal G3P[6] rotavirus vaccine administered in a neonatal schedule was...
8.
Azzopardi K, Hardy M, Baker C, Bonnici R, Llewellyn S, McCarthy J, et al.
PLoS One
. 2021 Sep;
16(9):e0258039.
PMID: 34591904
Soil-transmitted helminths (STH) infect up to one-quarter of the global population, with a significant associated disease burden. The main human STH are: Ancylostoma spp. and Necator americanus (hookworms); Ascaris lumbricoides,...
9.
Freyne B, Messina N, Donath S, Germano S, Bonnici R, Gardiner K, et al.
J Infect Dis
. 2020 Jan;
221(12):1999-2009.
PMID: 31990350
Background: BCG vaccination has beneficial nonspecific (heterologous) effects that protect against nonmycobacterial infections. We have previously reported that BCG vaccination at birth alters in vitro cytokine responses to heterologous stimulants...
10.
Messina N, Germano S, Bonnici R, Lee L, Daley A, Bustamante A, et al.
Tuberculosis (Edinb)
. 2018 Jul;
111:188-192.
PMID: 30029906
A recent shortage in supply of Bacille Calmette-Guérin (BCG), the live attenuated vaccine given to protect against tuberculosis (TB) caused major disruption to global vaccination programs. In this study, we...