Renato O Crajoinas
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Explore the profile of Renato O Crajoinas including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
329
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0
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Recent Articles
1.
Shimoura C, Oliveira T, Lincevicius G, Crajoinas R, Oliveira-Sales E, Varela V, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000071
The Goldblatt model of hypertension (2K-1C) in rats is characterized by renal sympathetic nerve activity (rSNA). We investigated the effects of unilateral renal denervation of the clipped kidney (DNX) on...
2.
Castro P, Santos-Rios T, Martins F, Crajoinas R, Caetano M, Lessa L, et al.
Am J Physiol Cell Physiol
. 2024 Apr;
326(6):C1573-C1589.
PMID: 38557357
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce blood pressure (BP) in patients with hypertension, yet the precise molecular mechanisms remain elusive. SGLT2i inhibits proximal tubule (PT) NHE3-mediated sodium reabsorption in normotensive rodents,...
3.
Pontes R, Nishi E, Crajoinas R, Milanez M, Girardi A, Campos R, et al.
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613793
We examined the effects of an acute increase in blood pressure (BP) and renal sympathetic nerve activity (rSNA) induced by bicuculline (Bic) injection in the paraventricular nucleus of hypothalamus (PVN)...
4.
Crestani T, Crajoinas R, Jensen L, Dima L, Burdeyron P, Hauet T, et al.
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502149
Chronic kidney disease (CKD) is a worldwide public health issue affecting 14% of the general population. However, research focusing on CKD mechanisms/treatment is limited because of a lack of animal...
5.
Borges-Junior F, Silva Dos Santos D, Benetti A, Polidoro J, Wisnivesky A, Crajoinas R, et al.
J Am Soc Nephrol
. 2021 Apr;
32(7):1616-1629.
PMID: 33846238
Background: SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit remain unclear. Experiments...
6.
Luchi W, Crajoinas R, Martins F, Castro P, Venturini G, Seguro A, et al.
J Hypertens
. 2020 Dec;
39(5):880-891.
PMID: 33337598
Objectives: Clinical and epidemiological studies have suggested a correlation between vitamin D deficiency (VDD) and high blood pressure (BP). This study aimed to test the hypothesis that high BP induced...
7.
Arruda-Junior D, Martins F, Salles T, Jensen L, Dariolli R, Antonio E, et al.
Clin Sci (Lond)
. 2020 May;
134(9):1081-1094.
PMID: 32352510
The relationship between disturbances in glucose homeostasis and heart failure (HF) progression is bidirectional. However, the mechanisms by which HF intrinsically impairs glucose homeostasis remain unknown. The present study tested...
8.
Crajoinas R, Polidoro J, Girardi A
Am J Physiol Renal Physiol
. 2019 Mar;
316(5):F986-F992.
PMID: 30864843
Isoform 3 of the Na/H exchanger (NHE3) is responsible for the majority of the reabsorption of NaCl, NaHCO, and, consequently, water in the renal proximal tubule. As such, this transporter...
9.
Savignano F, Crajoinas R, Pacheco B, Campos L, Shimizu M, Seguro A, et al.
Eur J Pharmacol
. 2017 Jun;
811:38-47.
PMID: 28576404
Accumulating evidence from clinical and experimental studies indicates that the incretin glucagon-like peptide-1 (GLP-1) elicits blood-pressure lowering effects via its diuretic, natriuretic and vasodilatory properties. The present study investigated whether...
10.
Crajoinas R, Polidoro J, Carneiro de Morais C, Castelo-Branco R, Girardi A
Am J Physiol Cell Physiol
. 2016 Aug;
311(5):C768-C776.
PMID: 27510906
Binding of angiotensin II (ANG II) to the AT receptor (ATR) in the proximal tubule stimulates Na/H exchanger isoform 3 (NHE3) activity through multiple signaling pathways. However, the effects of...