Renato Ivan de Avila
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Explore the profile of Renato Ivan de Avila including associated specialties, affiliations and a list of published articles.
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37
Citations
134
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Recent Articles
11.
Silva T, de Avila R, Zara A, Santos A, Ataides F, Freitas V, et al.
Braz J Microbiol
. 2020 Aug;
51(4):1719-1727.
PMID: 32856241
Punicalagin is a phenolic compound extracted from Lafoensia pacari A. St.-Hil (Lythraceae) leaves. It has demonstrated interesting activity against pathogenic fungi, e.g., Cryptococcus gattii and Candida albicans, by inhibiting fungi...
12.
de Oliveira Ribeiro H, Cortez A, de Avila R, da Silva A, de Carvalho F, Menegatti R, et al.
Fundam Clin Pharmacol
. 2020 Feb;
34(4):444-457.
PMID: 32011031
Our group designed and synthesized the N-phenyl-piperazine LQFM030 [1-(4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl) piperazin-1-yl) ethanone], a small molecule derived from molecular simplification of the Nutlin-1, an inhibitor of the human homologue of murine double...
13.
Lindberg T, de Avila R, Zeller K, Levander F, Eriksson D, Chawade A, et al.
J Proteomics
. 2020 Feb;
217:103647.
PMID: 32006680
We investigated the skin sensitization hazard of glyphosate, the surfactant polyethylated tallow amine (POEA) and two commercial glyphosate-containing formulations using different omics-technologies based on a human dendritic cell (DC)-like cell...
14.
de Avila R, Lindstedt M, Valadares M
Regul Toxicol Pharmacol
. 2019 Aug;
108:104445.
PMID: 31430506
In a regulatory context, skin sensitization hazard and risk evaluations of manufactured products and their ingredients (e.g. cosmetics) are mandatory in several regions. Great efforts have been made within the...
15.
de Avila R, Valadares M
Altern Lab Anim
. 2019 Jul;
47(2):71-81.
PMID: 31319697
In Brazil, efforts towards the regulatory acceptance and implementation of innovative methods to replace experimental animal use in various fields began to gather force in 2008, with the approval of...
16.
de Avila R, Veloso D, Teixeira G, Rodrigues T, Lindberg T, Lindstedt M, et al.
Contact Dermatitis
. 2019 Apr;
81(3):194-209.
PMID: 31006869
Background: Allergic contact dermatitis caused by henna-based hair-colouring products has been associated with adulteration of henna with p-phenylenediamine (PPD). Objectives: To develop a testing approach based on in vitro techniques...
17.
Silva T, de Sene Amancio Zara A, Sa F, Bara M, de Avila R, Costa C, et al.
Rev Inst Med Trop Sao Paulo
. 2018 Oct;
60:e60.
PMID: 30365643
This study evaluated the antifungal activity and cytotoxicity profile of the ellagitannin punicalagin, a compound extracted from the L. pacari A. St.-Hil (Lythraceae) leaf, against Cryptococcus neoformans species complex. Minimum...
18.
da Silva A, Chialchia A, de Avila R, Valadares M
Chem Biol Interact
. 2018 Jun;
292:1-8.
PMID: 29953848
Eye toxicity is a mandatory parameter in human risk and safety evaluation for products including chemicals, pesticides, medicines and cosmetics. Historically, this endpoint has been evaluated using the Draize rabbit...
19.
Dos Santos Rodrigues B, de Avila R, Benfica P, Bringel L, Alves de Oliveira C, Vandresen F, et al.
Life Sci
. 2018 Apr;
203:141-149.
PMID: 29674122
Aims: This study evaluated parameters of toxicity and antiproliferative effects of (+)-N(1)-4-fluorobenzaldehyde-N(4)-{1-methyl-1-[(1R)-4-methylcyclohexene-3-il]-ethyl}-thiossemicarbazone (4-FTSC) in PC-3 adenocarcinoma prostate cells. Main Methods: Cytotoxicity of 4-FTSC in PC-3 cells was evaluated using MTT...
20.
Costa F, Cortez A, de Avila R, de Carvalho F, Andrade W, da Cruz A, et al.
Biomed Pharmacother
. 2018 Mar;
102:481-493.
PMID: 29579709
Piperazine is a promising scaffold for drug development due to its broad spectrum of biological activities. Based on this, the new piperazine-containing compound LQFM018 (2) [ethyl 4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl)piperazine-1-carboxylate] was synthetized and...