Reisa Sperling
Overview
Explore the profile of Reisa Sperling including associated specialties, affiliations and a list of published articles.
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92
Citations
12005
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Recent Articles
1.
Coughlan G, Rubinstein Z, Klinger H, Lopez K, Hsieh S, Boyle R, et al.
Sci Adv
. 2025 Mar;
11(10):eadt1288.
PMID: 40043125
Elucidating the downstream impact of exogenous hormones on the aging brain will have far-reaching consequences for understanding why Alzheimer's disease (AD) predominates in women almost twofold over men. We tested...
2.
Grill J, Raman R, Flournoy C, Ernstrom K, Pierce A, Smith A, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e14623.
PMID: 39988989
Introduction: The long-term implications of disclosing Alzheimer's disease (AD) biomarker information to cognitively unimpaired individuals are unknown. Methods: We compared participants who disclosed their elevated amyloid imaging result in a...
3.
Siemers E, Feaster T, Sethuraman G, Sundell K, Skljarevski V, Cline E, et al.
J Prev Alzheimers Dis
. 2025 Jan;
12(1):100005.
PMID: 39800458
Background: Soluble species of multimeric amyloid-beta including globular amyloid-beta oligomers (AβOs) and linear amyloid-beta protofibrils are toxic to neurons. Sabirnetug (ACU193) is a humanized monoclonal antibody, raised against globular species...
4.
Aisen P, Bateman R, Crowther D, Cummings J, Dwyer J, Iwatsubo T, et al.
Alzheimers Dement
. 2024 Nov;
21(1):e14342.
PMID: 39535341
Decades of research have provided evidence that Alzheimer's disease (AD) is caused in part by cerebral accumulation of amyloid beta-protein (Aβ). In 2023, the US Food and Drug Administration gave...
5.
Gunasekaran T, Meena D, Lee A, Wu S, Dumitrescu L, Sperling R, et al.
medRxiv
. 2024 Oct;
PMID: 39417126
Background: Genetic research on Alzheimer's disease (AD) has primarily focused on amyloid-β (Aβ) pathogenesis, with fewer studies exploring tau pathology. Elucidating the genetic basis of tau pathology could identify novel...
6.
Nho K, Risacher S, Apostolova L, Bice P, Brosch J, Deardorff R, et al.
Nat Commun
. 2024 Sep;
15(1):8251.
PMID: 39304655
Determining the genetic architecture of Alzheimer's disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron...
7.
Fortea J, Vaque-Alcazar L, Pegueroles J, Alcolea D, Belbin O, Dols-Icardo O, et al.
Nat Med
. 2024 Jul;
30(11):3096-3097.
PMID: 39025967
No abstract available.
8.
Jack Jr C, Andrews S, Beach T, Buracchio T, Dunn B, Graf A, et al.
Nat Med
. 2024 Jun;
30(8):2121-2124.
PMID: 38942991
No abstract available.
9.
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
Jack Jr C, Scott Andrews J, Beach T, Buracchio T, Dunn B, Graf A, et al.
Alzheimers Dement
. 2024 Jun;
20(8):5143-5169.
PMID: 38934362
The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis...
10.
Fortea J, Pegueroles J, Alcolea D, Belbin O, Dols-Icardo O, Vaque-Alcazar L, et al.
Nat Med
. 2024 Jun;
30(7):2093.
PMID: 38886628
No abstract available.