Reinhard Luhrmann
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Explore the profile of Reinhard Luhrmann including associated specialties, affiliations and a list of published articles.
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185
Citations
12462
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Recent Articles
1.
Li Y, Fischer P, Wang M, Zhou Q, Song A, Yuan R, et al.
Cell Res
. 2025 Feb;
PMID: 40016598
The spliceosome, a highly dynamic macromolecular assembly, catalyzes the precise removal of introns from pre-mRNAs. Recent studies have provided comprehensive structural insights into the step-wise assembly, catalytic splicing and final...
2.
Zhang Z, Kumar V, Dybkov O, Will C, Zhong J, Ludwig S, et al.
Nature
. 2024 May;
630(8018):1012-1019.
PMID: 38778104
Early spliceosome assembly can occur through an intron-defined pathway, whereby U1 and U2 small nuclear ribonucleoprotein particles (snRNPs) assemble across the intron. Alternatively, it can occur through an exon-defined pathway,...
3.
Atkinson R, Georgiou M, Yang C, Szymanska K, Lahat A, Vasconcelos E, et al.
Nat Commun
. 2024 Apr;
15(1):3138.
PMID: 38605034
The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity...
4.
Zhang Z, Kumar V, Dybkov O, Will C, Urlaub H, Stark H, et al.
EMBO J
. 2024 Feb;
43(6):1065-1088.
PMID: 38383864
The B complex is a key intermediate stage of spliceosome assembly. To improve the structural resolution of monomeric, human spliceosomal B (hB) complexes and thereby generate a more comprehensive hB...
5.
Dybkov O, Preussner M, El Ayoubi L, Feng V, Harnisch C, Merz K, et al.
Sci Adv
. 2023 Mar;
9(9):eadf1785.
PMID: 36867703
Alternative precursor messenger RNA splicing is instrumental in expanding the proteome of higher eukaryotes, and changes in 3' splice site (3'ss) usage contribute to human disease. We demonstrate by small...
6.
Georgiou M, Yang C, Atkinson R, Pan K, Buskin A, Moya Molina M, et al.
Clin Transl Med
. 2022 Mar;
12(3):e759.
PMID: 35297555
Introduction: Mutations in pre-mRNA processing factor 31 (PRPF31), a core protein of the spliceosomal tri-snRNP complex, cause autosomal-dominant retinitis pigmentosa (adRP). It has remained an enigma why mutations in ubiquitously...
7.
Zhang Z, Rigo N, Dybkov O, Fourmann J, Will C, Kumar V, et al.
Nature
. 2021 Aug;
596(7871):296-300.
PMID: 34349264
During the splicing of introns from precursor messenger RNAs (pre-mRNAs), the U2 small nuclear ribonucleoprotein (snRNP) must undergo stable integration into the spliceosomal A complex-a poorly understood, multistep process that...
8.
Cossa G, Roeschert I, Prinz F, Baluapuri A, Vidal R, Schulein-Volk C, et al.
Mol Cell
. 2021 Jun;
81(11):2495.
PMID: 34087181
No abstract available.
9.
Yildirim A, Mozaffari-Jovin S, Wallisch A, Schafer J, Ludwig S, Urlaub H, et al.
Nucleic Acids Res
. 2021 May;
49(10):5845-5866.
PMID: 34023904
Splicing is catalyzed by the spliceosome, a compositionally dynamic complex assembled stepwise on pre-mRNA. We reveal links between splicing machinery components and the intrinsically disordered ciliopathy protein SANS. Pathogenic mutations...
10.
Zhang S, Aibara S, Vos S, Agafonov D, Luhrmann R, Cramer P
Science
. 2021 Jan;
371(6526):305-309.
PMID: 33446560
To initiate cotranscriptional splicing, RNA polymerase II (Pol II) recruits the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to nascent precursor messenger RNA (pre-mRNA). Here, we report the cryo-electron microscopy...