Reinaldo Sousa Dos Santos
Overview
Explore the profile of Reinaldo Sousa Dos Santos including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
279
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Recent Articles
1.
Garcia-Gutierrez E, OMahony A, Dos Santos R, Marroqui L, Cotter P
Gut Microbes
. 2024 Oct;
16(1):2401654.
PMID: 39420751
Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), type 2 diabetes (T2D) and gestational...
2.
Dos Santos R, Babiloni-Chust I, Marroqui L, Nadal A
Int J Mol Sci
. 2023 Jan;
24(1).
PMID: 36613676
Metabolism-disrupting chemicals (MDCs) are endocrine disruptors with obesogenic and/or diabetogenic action. There is mounting evidence linking exposure to MDCs to increased susceptibility to diabetes. Despite the important role of glucagon...
3.
Dos Santos R, Medina-Gali R, Babiloni-Chust I, Marroqui L, Nadal A
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563431
There is a need to develop identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity. Here we used the human EndoC-βH1 β-cell line, the rat β-cell line INS-1E and...
4.
Marroqui L, Perez-Serna A, Babiloni-Chust I, Dos Santos R
Int Rev Cell Mol Biol
. 2021 Apr;
359:1-80.
PMID: 33832648
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by pancreatic islet inflammation (insulitis) and specific pancreatic β-cell destruction by an immune attack. Although the precise underlying mechanisms leading...
5.
Marroqui L, Tuduri E, Alonso-Magdalena P, Quesada I, Nadal A, Dos Santos R
J Endocrinol
. 2018 Aug;
239(2):R27-R45.
PMID: 30072426
Type 2 diabetes is a chronic, heterogeneous syndrome characterized by insulin resistance and pancreatic β-cell dysfunction or death. Among several environmental factors contributing to type 2 diabetes development, endocrine-disrupting chemicals...
6.
Pecanha F, Dos Santos R, da-Silva W
Endocr Connect
. 2017 May;
6(5):311-322.
PMID: 28483784
The thyroid hormones (THs), triiodothyronine (T) and thyroxine (T), are very important in organism metabolism and regulate glucose utilization. Hexokinase (HK) is responsible for the first step of glycolysis, catalyzing...
7.
Dos Santos R, Daures M, Philippi A, Romero S, Marselli L, Marchetti P, et al.
Diabetes
. 2017 Jan;
66(4):1086-1096.
PMID: 28073829
We describe a new syndrome characterized by early-onset diabetes associated with bone marrow failure, affecting mostly the erythrocytic lineage. Using whole-exome sequencing in a remotely consanguineous patient from a family...
8.
Marroqui L, Dos Santos R, Floyel T, Grieco F, Santin I, Op de Beeck A, et al.
Diabetes
. 2015 Aug;
64(11):3808-17.
PMID: 26239055
Pancreatic β-cells are destroyed by an autoimmune attack in type 1 diabetes. Linkage and genome-wide association studies point to >50 loci that are associated with the disease in the human...
9.
Marroqui L, Santin I, Dos Santos R, Marselli L, Marchetti P, Eizirik D
Diabetes
. 2014 Mar;
63(7):2516-27.
PMID: 24608439
Type 1 diabetes is a chronic autoimmune disease characterized by specific destruction of pancreatic β-cells by the immune system. Linkage and genome-wide association studies have identified more than 50 loci...
10.
Dos Santos R, Pecanha F, da-Silva W
J Bioenerg Biomembr
. 2013 Apr;
45(3):243-51.
PMID: 23609063
Uncoupling proteins (UCP) are able to increase H(+) leakage across the inner mitochondrial membrane, thus dissipating the membrane potential and increasing oxygen consumption. Despite the identification of several UCP orthologs...