Reinaldo S Dos Santos
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Explore the profile of Reinaldo S Dos Santos including associated specialties, affiliations and a list of published articles.
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14
Citations
444
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Recent Articles
1.
Perez-Serna A, Guzman-Llorens D, Dos Santos R, Marroqui L
Biomedicines
. 2025 Jan;
13(1).
PMID: 39857806
Diabetes is a chronic metabolic disorder whose prevalence increases every year, affecting more than 530 million adults worldwide. Type 1 (T1D) and type 2 diabetes (T2D), the most common forms...
2.
Dos Santos R, Guzman-Llorens D, Perez-Serna A, Nadal A, Marroqui L
Front Immunol
. 2023 Oct;
14:1263926.
PMID: 37854597
Introduction: Type 1 diabetes is characterized by pancreatic islet inflammation and autoimmune-driven pancreatic β-cell destruction. Interferon-α (IFNα) is a key player in early human type 1 diabetes pathogenesis. IFNα activates...
3.
Perez-Serna A, Dos Santos R, Ripoll C, Nadal A, Eizirik D, Marroqui L
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982731
Diabetes is a chronic disease that affects glucose metabolism, either by autoimmune-driven β-cell loss or by the progressive loss of β-cell function, due to continued metabolic stresses. Although both α-...
4.
Babiloni-Chust I, Dos Santos R, Medina-Gali R, Perez-Serna A, Encinar J, Martinez-Pinna J, et al.
Environ Int
. 2022 Apr;
164:107250.
PMID: 35461094
17β-estradiol protects pancreatic β-cells from apoptosis via the estrogen receptors ERα, ERβ and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA), which exerts multiple effects in this cell type via the...
5.
Marroqui L, Martinez-Pinna J, Castellano-Munoz M, Dos Santos R, Medina-Gali R, Soriano S, et al.
Chemosphere
. 2020 Nov;
265:129051.
PMID: 33250229
Bisphenol-S (BPS) and Bisphenol-F (BPF) are current Bisphenol-A (BPA) substitutes. Here we used pancreatic β-cells from wild type (WT) and estrogen receptor β (ERβ) knockout (BERKO) mice to investigate the...
6.
Bru-Tari E, Cobo-Vuilleumier N, Alonso-Magdalena P, Dos Santos R, Marroqui L, Nadal A, et al.
Sci Rep
. 2019 Jul;
9(1):9515.
PMID: 31266981
Most studies in type 1 diabetes (T1D) have focused on the loss of the pancreatic beta-cell population. However, despite the involvement of the alpha-cell in the aetiology and complications of...
7.
Martinez-Pinna J, Marroqui L, Hmadcha A, Lopez-Beas J, Soriano S, Villar-Pazos S, et al.
Diabetologia
. 2019 Jun;
62(9):1667-1680.
PMID: 31250031
Aims/hypothesis: Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical that has been associated with type 2 diabetes development. Low doses of BPA modify pancreatic beta cell function and induce insulin resistance;...
8.
Dos Santos R, Marroqui L, Velayos T, Olazagoitia-Garmendia A, Jauregi-Miguel A, Castellanos-Rubio A, et al.
Diabetologia
. 2018 Nov;
62(3):459-472.
PMID: 30478640
Aims/hypothesis: The initial stages of type 1 diabetes are characterised by an aberrant islet inflammation that is in part regulated by the interaction between type 1 diabetes susceptibility genes and...
9.
Tuduri E, Marroqui L, Dos Santos R, Quesada I, Fuentes E, Alonso-Magdalena P
Front Endocrinol (Lausanne)
. 2018 Nov;
9:648.
PMID: 30429829
Bisphenol-A (BPA) is one of the most widespread endocrine disrupting chemicals (EDCs). It is used as the base compound in the production of polycarbonate and other plastics present in many...
10.
Colli M, Hill J, Marroqui L, Chaffey J, Dos Santos R, Leete P, et al.
EBioMedicine
. 2018 Oct;
36:367-375.
PMID: 30269996
Background: Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is...