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Rebecca E Brown

Explore the profile of Rebecca E Brown including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 316
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Recent Articles
1.
Brown R, Coxon M, Larsen B, Allison M, Chadha A, Mittelstadt I, et al.
Proc Natl Acad Sci U S A . 2025 Jan; 122(2):e2408179122. PMID: 39772743
CAG/CTG repeats are prone to expansion, causing several inherited human diseases. The initiating sources of DNA damage which lead to inaccurate repair of the repeat tract to cause expansions are...
2.
Tak Y, Lal S, Gopan S, Balakrishnan M, Satheesh G, Biswal A, et al.
J Exp Bot . 2022 Dec; 74(5):1705-1722. PMID: 36576197
J-domain proteins (JDPs) are critical components of the cellular protein quality control machinery, playing crucial roles in preventing the formation and, solubilization of cytotoxic protein aggregates. Bacteria, yeast, and plants...
3.
Brown R, Su X, Fair S, Wu K, Verra L, Jong R, et al.
PLoS Biol . 2022 Dec; 20(12):e3001940. PMID: 36574440
Expansion of structure-forming CAG/CTG repetitive sequences is the cause of several neurodegenerative disorders and deletion of repeats is a potential therapeutic strategy. Transcription-associated mechanisms are known to cause CAG repeat...
4.
Brown R, Freudenreich C
Curr Opin Genet Dev . 2020 Dec; 67:41-51. PMID: 33279816
Repetitive sequences throughout the genome are a major source of endogenous DNA damage, due to the propensity of many of them to form alternative non-B DNA structures that can interfere...
5.
Verma A, Diwan D, Raut S, Dobriyal N, Brown R, Gowda V, et al.
G3 (Bethesda) . 2017 Apr; 7(6):1941-1954. PMID: 28450372
Heat shock proteins of 70 kDa (Hsp70s) partner with structurally diverse Hsp40s (J proteins), generating distinct chaperone networks in various cellular compartments that perform myriad housekeeping and stress-associated functions in...
6.
Jin J, Hjerrild K, Silk S, Brown R, Labbe G, Marshall J, et al.
Int J Parasitol . 2017 Feb; 47(7):435-446. PMID: 28153778
Development of bespoke biomanufacturing processes remains a critical bottleneck for translational studies, in particular when modest quantities of a novel product are required for proof-of-concept Phase I/II clinical trials. In...
7.
Hjerrild K, Jin J, Wright K, Brown R, Marshall J, Labbe G, et al.
Sci Rep . 2016 Jul; 6:30357. PMID: 27457156
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. However it has proved challenging to identify a...
8.
Payne R, Milne K, Elias S, Edwards N, Douglas A, Brown R, et al.
J Infect Dis . 2016 Feb; 213(11):1743-51. PMID: 26908756
Background: Models of controlled human malaria infection (CHMI) initiated by mosquito bite have been widely used to assess efficacy of preerythrocytic vaccine candidates in small proof-of-concept phase 2a clinical trials....
9.
Wright K, Hjerrild K, Bartlett J, Douglas A, Jin J, Brown R, et al.
Nature . 2014 Aug; 515(7527):427-30. PMID: 25132548
Invasion of host erythrocytes is essential to the life cycle of Plasmodium parasites and development of the pathology of malaria. The stages of erythrocyte invasion, including initial contact, apical reorientation,...
10.
Brown R, Willis T, Aspinall N, Candida H, George J, Rudolf M
Community Pract . 2013 Aug; 86(7):23-7. PMID: 23914474
Childhood obesity has reached epidemic levels, yet many health professionals lack confidence in working with parents around lifestyle change. HENRY (Health Exercise Nutrition for the Really Young) aims to tackle...